Utility of Maoto in an influenza season where reduced effectiveness of oseltamivir was observed - a clinical, non-randomized study in children.

Abstract

BACKGROUND:

In an influenza season where reduced effectiveness of oseltamivir was observed, we investigated the effectiveness of Maoto for influenza infection in children.

METHODS:

Patients diagnosed with influenza by rapid diagnostic kit underwent treatment in one of the following groups: Maoto-treated group (group 1 (M)); oseltamivir-treated group (group 2 (O)); Maoto+oseltamivir-treated group (group 3 (M+O)); zanamivir-treated group (group 4 (Z)); and Maoto+zanamivir-treated group (group 5 (M+Z)).

RESULTS:

In influenza A patients who completed the study (n = 150), the mean duration of fever after administration (DFA) was significantly shorter in group 3 (M+O) (31.1 h, p < 0.01) and in group 4 (Z) (35.2 h, p < 0.05), as compared to group 2 (O) (56.0 h). Among these, in patients aged ≤5 years (n = 54), DFA was significantly shorter in group 1 (M) (33.2 h, p < 0.05) and in group 3 (M+O) (34.6 h, p < 0.05), as compared to group 2 (O) (61.4 h). In influenza B patients who completed the study (n = 70), no significant differences in DFA were observed among the groups.

CONCLUSION:

Maoto may be useful, particularly in cases of influenza with low sensitivity to oseltamivir and in patients aged ≤5 years for whom the use of zanamivir is difficult.

• Authors: Yoshitaka Toriumi, Tsutomu Kamei, Kohji Murata, Ikuko Takahashi, Nobutaka Suzuki, Osam Mazda
• Journal: Forschende Komplementarmedizin (2006) (Forsch Komplementmed) Vol. 19 Issue 4 Pg. 179-86 ( 2012) ISSN: 1661-4127 [Electronic] Switzerland
• PMID: 22964983 (Publication Type: Comparative Study, Controlled Clinical Trial, Journal Article)
• Copyright: Copyright © 2012 S. Karger AG, Basel.

Chemical References

• Antiviral Agents
• Drugs, Chinese Herbal
• Mao-to
• Oseltamivir
• Zanamivir

Topics

• Administration, Inhalation
• Administration, Oral
• Adolescent
• Age Factors
• Antiviral Agents (therapeutic use)
• Child
• Child, Preschool
• Drug Therapy, Combination
• Drugs, Chinese Herbal (therapeutic use)
• Female
• Humans
• Infant
• Influenza, Human (drug therapy)
• Influenzavirus A (drug effects)
• Influenzavirus B (drug effects)
• Male
• Oseltamivir (therapeutic use)
• Seasons
• Treatment Outcome
• Zanamivir (therapeutic use)