Abstract | CONTEXT: The small intestine in chronic pancreatitis has not been investigated yet thoroughly. It would be important to understand fat metabolism in the course of this disease and could be explained if the small intestine has some pathological conditions and, due to this reason, pancreatic enzyme substitution does not work in all patients. OBJECTIVE: To investigate the pathophysiology of small intestine in chronic pancreatitis and to show the reason why in some cases pancreatic enzyme substitution does not work properly. PATIENTS: CONTROLS: INVESTIGATIONS: Aspiration biopsy of jejunum mucosa followed by histological examination and investigation of intestinal enzymes by aspiration has been performed. MAIN OUTCOME MEASURES: RESULTS: Secondary enteritis, accompanied by moderate dystrophic changes of mucous membrane, thinning of limbus, and decrease of Paneth cell mitotic index, was found to occur in chronic pancreatitis patients. Enteritis is followed by changes in enzymatic processes in the sphere of membrane and intestinal digestion, decrease of absorption, accelerated desquamation of epithelium, fall in local immunity and development of bacterial overgrowth syndrome. CONCLUSIONS:
|
Authors | Natalya B Gubergrits, Yuri V Linevskiy, Galina M Lukashevich, Pavel G Fomenko, Tatyana V Moroz, Tapan Mishra |
Journal | JOP : Journal of the pancreas
(JOP)
Vol. 13
Issue 5
Pg. 519-28
(Sep 10 2012)
ISSN: 1590-8577 [Electronic] Italy |
PMID | 22964959
(Publication Type: Journal Article)
|
Chemical References |
- Xylose
- Lipase
- Alkaline Phosphatase
- Amylases
|
Topics |
- Adolescent
- Adult
- Alkaline Phosphatase
(metabolism)
- Amylases
(metabolism)
- Colony Count, Microbial
- Enteritis
(metabolism, physiopathology)
- Enterocytes
(enzymology, metabolism, microbiology)
- Female
- Humans
- Intestinal Absorption
- Intestinal Mucosa
(metabolism, pathology, physiopathology)
- Intestine, Small
(metabolism, pathology, physiopathology)
- Jejunum
(metabolism, pathology, physiopathology)
- Lipase
(metabolism)
- Male
- Middle Aged
- Mitotic Index
- Pancreatitis, Chronic
(metabolism, physiopathology)
- Paneth Cells
(metabolism)
- Xylose
(metabolism, pharmacokinetics)
- Young Adult
|