Clinical recovery of chronic intestinal pseudo-obstruction with cisapride in a complex pediatric patient.

Abstract

Cisapride is a gastrointestinal prokinetic that facilitates or restores motility along the entire gastrointestinal tract. It has been used successfully to treat acute and chronic intestinal pseudo-obstructions (CIPs) in adults, but there is a paucity of literature surrounding the treatment of CIP in pediatric patients and therapies for CIP are limited and their impact is often unsatisfactory. This case report presents the use of cisapride in the management of pseudo-obstruction. Treatment with cisapride substantially improved the patient's symptoms and improved feeding tolerance. It improved his prognosis remarkably and prevented the need for end-of-life care. He experienced no adverse effects throughout the course of therapy. The treatment regimen is discussed in this case report.

• Authors: Jean-Christy F Cameron, Régis Vaillancourt, Nathalie Major-Cook, Margaret Boland, Marc Zucker, Doris Lariviere
• Journal: The American journal of hospice & palliative care (Am J Hosp Palliat Care) Vol. 30 Issue 4 Pg. 403-5 (Jun 2013) ISSN: 1938-2715 [Electronic] United States
• PMID: 22964344 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antacids
• Antiemetics
• Gastrointestinal Agents
• Domperidone
• Magnesium Hydroxide
• Cisapride

Topics

• Antacids (administration & dosage)
• Antiemetics (administration & dosage)
• Child
• Cisapride (administration & dosage, therapeutic use)
• Domperidone (administration & dosage)
• Gastrointestinal Agents (administration & dosage, therapeutic use)
• Gastrointestinal Motility (drug effects)
• Gastrostomy
• Humans
• Hypopituitarism (complications, congenital, therapy)
• Intestinal Pseudo-Obstruction (diagnosis, drug therapy)
• Intubation, Gastrointestinal
• Magnesium Hydroxide (administration & dosage)
• Male