Abstract | BACKGROUND: Whether antibody to myelin oligodendrocyte glycoprotein (MOG) can be a diagnostic marker for multiple sclerosis (MS) is still controversial. Recent studies suggested that serum specific anti-MOG epitope antibody might be an MS specific marker. However, these studies did not include neuromyelitis optica (NMO) which might be proven to also have anti-MOG antibody. Hence, the present study was undertaken to investigate the clinical value of serum antibodies to 25 MOG epitopes in conventional MS (CMS) and NMO. METHODS: Serum anti-MOG epitope IgG was detected in 61 CMS patients, 54 NMO patients, and 77 healthy controls, using enzyme-linked immunosorbent assay (ELISA). RESULTS: Anti-MOG(27-38) IgG levels in both CMS and NMO patients were significantly higher than that in healthy controls (optical density (OD): 0.64 ± 0.38, 0.48 ± 0.23 vs. 0.19 ± 0.09; P = 0.000). CMS and NMO patients in relapse stage had significantly higher anti-MOG(27-38) IgG level than patients in remission stage (OD: 0.55 ± 0.14 vs. 0.24 ± 0.09, P = 0.027). CONCLUSION: Although serum anti-MOG epitope IgG could not differentiate MS from NMO, it may be a useful marker for monitoring disease activity.
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Authors | Yan Xu, Yao Zhang, Cai-yan Liu, Bin Peng, Jian-ming Wang, Xiao-jun Zhang, Hai-feng Li, Li-ying Cui |
Journal | Chinese medical journal
(Chin Med J (Engl))
Vol. 125
Issue 18
Pg. 3207-10
(Sep 2012)
ISSN: 2542-5641 [Electronic] China |
PMID | 22964310
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antibodies
- Epitopes
- Myelin-Oligodendrocyte Glycoprotein
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Topics |
- Adult
- Antibodies
(blood, immunology)
- Epitopes
(immunology)
- Female
- Humans
- Male
- Middle Aged
- Multiple Sclerosis
(blood, immunology)
- Myelin-Oligodendrocyte Glycoprotein
(immunology)
- Neuromyelitis Optica
(blood, immunology)
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