[Intrasellar gangliocytoma associated with growth hormone-producing pituitary adenoma. Case report].

Abstract

INTRODUCTION:

Intrasellar gangliocytomas are uncommon entities which, unusually, may be found in association with hormone-releasing pituitary adenomas.

CASE REPORT:

The patient was a 49-year-old female who presented a sellar lesion with associated acromegaly. A trans-sphenoidal tumour was removed, with no medical improvement. Histopathological analysis revealed a gangliocytoma with an associated somatotroph adenoma.

DISCUSSION:

We found 85 cases of intrasellar gangliocytomas with associated hormone-releasing pituitary adenomas reported in the literature, with the following distribution: 50 growth hormone-releasing (GH) cases (59%), 15 mixed (GH and prolactin-releasing) cases (17%), 11 prolactin-releasing cases (13%), 7 adrenocorticotropic hormone-releasing (ACTH) cases (8%) and 2 corticotropin hormone-releasing (CRH) cases (2%).

CONCLUSIONS:

Mixed gangliocytomas-adenomas are uncommon entities. Association with growth hormone-releasing cases is more frequent and the most common presentation is among middle-aged females. Diagnosis is histopathological. Identification of this entity is important because it may lead to a limitation in therapeutic response in incomplete resections.

• Authors: Lorena Romero, Andrea Arcos, María Dolores Bautista, Miguel Domínguez, Juan M Medina, Miguel A Arráez
• Journal: Neurocirugia (Asturias, Spain) (Neurocirugia (Astur)) Vol. 23 Issue 6 Pg. 264-9 (Nov 2012) ISSN: 1130-1473 [Print] Spain
• Vernacular Title: Gangliocitoma selar asociado a adenoma hipofisario productor de hormona de crecimiento. Caso clínico.
• PMID: 22963951 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright © 2012 Sociedad Española de Neurocirugía. Published by Elsevier España. All rights reserved.

Chemical References

• Growth Hormone

Topics

• Acromegaly
• Adenoma
• Ganglioneuroma
• Growth Hormone
• Humans
• Pituitary Neoplasms (surgery)