Cannabidiolic acid, a major cannabinoid in fiber-type cannabis, is an inhibitor of MDA-MB-231 breast cancer cell migration.

Abstract

Cannabidiol (CBD), a major non-psychotropic constituent of fiber-type cannabis plant, has been reported to possess diverse biological activities, including anti-proliferative effect on cancer cells. Although CBD is obtained from non-enzymatic decarboxylation of its parent molecule, cannabidiolic acid (CBDA), few studies have investigated whether CBDA itself is biologically active. Results of the current investigation revealed that CBDA inhibits migration of the highly invasive MDA-MB-231 human breast cancer cells, apparently through a mechanism involving inhibition of cAMP-dependent protein kinase A, coupled with an activation of the small GTPase, RhoA. It is established that activation of the RhoA signaling pathway leads to inhibition of the mobility of various cancer cells, including MDA-MB-231 cells. The data presented in this report suggest for the first time that as an active component in the cannabis plant, CBDA offers potential therapeutic modality in the abrogation of cancer cell migration, including aggressive breast cancers.

• Authors: Shuso Takeda, Shunsuke Okajima, Hiroko Miyoshi, Kazutaka Yoshida, Yoshiko Okamoto, Tomoko Okada, Toshiaki Amamoto, Kazuhito Watanabe, Curtis J Omiecinski, Hironori Aramaki
• Journal: Toxicology letters (Toxicol Lett) Vol. 214 Issue 3 Pg. 314-9 (Nov 15 2012) ISSN: 1879-3169 [Electronic] Netherlands
• PMID: 22963825 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
• Copyright: Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

Chemical References

• Antineoplastic Agents
• Cannabinoids
• Enzyme Inhibitors
• rho-Associated Kinases
• Cyclic AMP-Dependent Protein Kinases
• cannabidiolic acid

Topics

• Adenocarcinoma (drug therapy)
• Antineoplastic Agents (pharmacology)
• Breast Neoplasms (drug therapy)
• Cannabinoids (pharmacology)
• Cell Movement (drug effects)
• Cell Proliferation (drug effects)
• Cell Survival (drug effects)
• Cyclic AMP-Dependent Protein Kinases (antagonists & inhibitors)
• Drug Screening Assays, Antitumor
• Enzyme Inhibitors (pharmacology)
• Female
• Humans
• MCF-7 Cells
• Signal Transduction
• rho-Associated Kinases (biosynthesis)