Inhibition of mouse urinary bladder carcinogenesis by açai fruit (Euterpe oleraceae Martius) intake.

Abstract

Açai, fruit from Euterpe oleraceae Martius, is consumed in natura and in a variety of beverages and food preparations and possesses several potential antioxidant compounds. In a first study for anticarcinogenicity screening, male Swiss mice (n = 20/per group) were chemically-induced to urothelial bladder carcinogenesis for 10 weeks and received a standard diet or a standard diet containing 2.5 and 5 % spray-dried açai pulp (AP) for 10 weeks. At week 20, the incidence of simple and nodular hyperplasia and the incidence and multiplicity of transitional cell carcinoma (TCC) were evaluated. In a second study for antigenotoxicity screening, male Swiss mice (n = 6/per group) were fed standard diet or standard diet containing 5 % AP for three weeks. Urothelial cell suspensions were obtained and challenged with H(2)O(2) for induction of DNA damage and analyzed by comet assay. Overall, dietary 5 % AP reduced TCC incidence and multiplicity (p = 0.019 and p = 0.015, respectively) and tumor cell proliferation and p63 expression (p = 0.02 and p = 0.007, respectively), Furthermore, the group fed the 5 % AP presented a significant reduction (p < 0.01) in DNA damage induced by H(2)O(2), a notable oxidant agent. The results suggest that the spray-dried açai pulp used here inhibits the TCC development in male Swiss mice, probably due to its potential antioxidant action.

• Authors: Mariana F Fragoso, Monize G Prado, Luciano Barbosa, Noeme S Rocha, Luis F Barbisan
• Journal: Plant foods for human nutrition (Dordrecht, Netherlands) (Plant Foods Hum Nutr) Vol. 67 Issue 3 Pg. 235-41 (Sep 2012) ISSN: 1573-9104 [Electronic] Netherlands
• PMID: 22961050 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anticarcinogenic Agents
• Antineoplastic Agents, Phytogenic
• Antioxidants
• Phosphoproteins
• Plant Preparations
• Trans-Activators
• Trp63 protein, mouse
• Hydrogen Peroxide

Topics

• Animals
• Anticarcinogenic Agents (pharmacology, therapeutic use)
• Antineoplastic Agents, Phytogenic (pharmacology, therapeutic use)
• Antioxidants (pharmacology, therapeutic use)
• Arecaceae
• Carcinoma, Transitional Cell (metabolism, prevention & control)
• Cell Proliferation (drug effects)
• Comet Assay
• DNA Damage (drug effects)
• Diet
• Epithelial Cells (drug effects, metabolism)
• Fruit
• Hydrogen Peroxide
• Hyperplasia
• Male
• Mice
• Mice, Inbred Strains
• Phosphoproteins (metabolism)
• Phytotherapy
• Plant Preparations (pharmacology, therapeutic use)
• Trans-Activators (metabolism)
• Urinary Bladder (cytology, drug effects, metabolism)
• Urinary Bladder Neoplasms (chemically induced, metabolism, prevention & control)