Neuroprotective effects of Schisandrin B against transient focal cerebral ischemia in Sprague-Dawley rats.

Abstract

Fruits of Schisandra have been traditionally used in East Asia for the treatment of dyspnea, cough, dysentery, insomnia, tonic-clonic seizures, and amnesia. Schisandrin B, a dibenzocyclooctadiene derivative isolated from Fructus Schisandrae, has been shown to produce antioxidant effect on rodent liver and heart. In the present study, we investigated the neuroprotective effects of Schisandrin B, a constituent drug of the fruit of Schisandra, against focal cerebral ischemia in rats. Schisandrin B (10, 30 mg/kg, i.p.) was twice administered 30 min before the onset of ischemia and 2h after reperfusion. Schisandrin B 10 and 30 mg/kg treated groups showed infarct volumes reduced by 25.7% and 53.4%, respectively, 2h after occlusion. Also, Schisandrin B treated animal treatment abrogated protein expression of TNF-α and IL-1β and degradation of MMP-2 and MMP-9 in ischemic hemispheres. These results suggest that Schisandrin B treatment provides a neuroprotective effect to rats after transient focal cerebral ischemia by inhibiting inflammation and by protecting against metalloproteinase degradation.

• Authors: Tae Hwa Lee, Chang Hwa Jung, Dae-Hee Lee
• Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association (Food Chem Toxicol) Vol. 50 Issue 12 Pg. 4239-45 (Dec 2012) ISSN: 1873-6351 [Electronic] England
• PMID: 22960133 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2012. Published by Elsevier Ltd.

Chemical References

• Antioxidants
• Cyclooctanes
• Drugs, Chinese Herbal
• Interleukin-1beta
• Lignans
• Neuroprotective Agents
• Plant Extracts
• Polycyclic Compounds
• Tumor Necrosis Factor-alpha
• schizandrin B
• Matrix Metalloproteinase 2
• Mmp2 protein, rat
• Matrix Metalloproteinase 9
• Mmp9 protein, rat

Topics

• Animals
• Antioxidants (pharmacology)
• Cerebral Infarction (drug therapy)
• Cyclooctanes (pharmacology)
• Drugs, Chinese Herbal (pharmacology)
• Inflammation (drug therapy)
• Interleukin-1beta (genetics, metabolism)
• Ischemic Attack, Transient (drug therapy)
• Lignans (pharmacology)
• Male
• Matrix Metalloproteinase 2 (genetics, metabolism)
• Matrix Metalloproteinase 9 (genetics, metabolism)
• Neuroprotective Agents (pharmacology)
• Plant Extracts (pharmacology)
• Polycyclic Compounds (pharmacology)
• Rats
• Rats, Sprague-Dawley
• Reperfusion (methods)
• Schisandra (chemistry)
• Tumor Necrosis Factor-alpha (genetics, metabolism)