HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Photodynamic therapy in urology: what can we do now and where are we heading?

AbstractBACKGROUND:
Photodynamic therapy (PDT) is an innovative technique in oncologic urology. Its application appears increasingly realistic to all kind of cancers with technological progress made in treatment planning and light delivery associated with the emergence of novel photosensitizers. The aim of this study is to review applications of this technique in urology.
MATERIALS AND METHODS:
We reviewed the literature on PDT for urological malignancies with the following key words: photodynamic therapy, prostate cancer, kidney cancer, urothelial cancer, penile cancer and then by cross-referencing from previously identified studies.
RESULTS:
Focal therapy of prostate cancer is an application of PDT. Clinical studies are ongoing to determine PDT efficacy and safety. PDT as salvage treatment after radiotherapy has been tested. Oncologic results were promising but important side effects were reported. Individual dosimetric planning is necessary to avoid toxicity. PDT was tested to treat superficial bladder carcinoma with promising oncologic results. Serious side effects have limited use of first photosensitizers generation. Second generation of photosensitizer allowed reducing morbidity. For upper urinary tract carcinoma and urethra, data are limited. Few studies described PDT application in penile oncology for conservative management of carcinoma in situ and premalignant lesions. For renal cancer, PDT was only tested on preclinical model despite of its potential application. No data is available concerning PDT application for testicular cancer.
CONCLUSION:
PDT clinical applications in urology have proved a kind of efficiency balanced with an important morbidity. Development of new photosensitizer generations and improvement in illumination protocols should permit to decrease side effects.
AuthorsG Bozzini, P Colin, N Betrouni, P Nevoux, A Ouzzane, P Puech, A Villers, S Mordon
JournalPhotodiagnosis and photodynamic therapy (Photodiagnosis Photodyn Ther) Vol. 9 Issue 3 Pg. 261-73 (Sep 2012) ISSN: 1873-1597 [Electronic] Netherlands
PMID22959806 (Publication Type: Journal Article, Meta-Analysis, Review)
CopyrightCopyright © 2012 Elsevier B.V. All rights reserved.
Chemical References
  • Photosensitizing Agents
Topics
  • Evidence-Based Medicine
  • Humans
  • Medical Oncology (trends)
  • Photochemotherapy (trends)
  • Photosensitizing Agents (therapeutic use)
  • Urologic Neoplasms (drug therapy)
  • Urology (trends)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: