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Dynamin 2 expression as a biomarker in grading of cervical intraepithelial neoplasia.

AbstractOBJECTIVE:
Dynamin 2, which plays a role in endocytosis, is known to be required for HPV infection on host cells. We investigated dynamin 2 as a biomarker in grading of cervical intraepithelial neoplasia (CIN) by comparing with Ki-67 expression and the type of HPV infection (low-risk vs. high-risk).
STUDY DESIGN:
We performed immunohistochemical stains of dynamin 2 and Ki-67 on tumor samples of patients with CIN and the type of HPV infection was investigated.
RESULTS:
All the patients with reactive changes (n=7) or normal (n=4) did not show dynamin 2 expression. There were 33, 14, and 12 cases with CIN I, II, and III, respectively, and there was a negative correlation between the degree of dynamin 2 expression and the severity of CIN lesions with statistical significance (P<0.001). Negative expression of dynamin 2 was more sensitive for the detection of CIN II/III than high expression (2+) of Ki-67 (96.2% vs. 73.1%, P=0.041). Among patients in whom HPV infection was detected, the degrees of dynamin 2 expression were not associated with the type of HPV infection (low-risk vs. high-risk). Overall, there was a negative correlation between the expression patterns of Ki-67 and dynamin 2.
CONCLUSION:
We found that dynamin 2 may be a helpful biomarker in grading of CIN lesions and a candidate biomarker for detecting low grade CIN with high sensitivity.
AuthorsYoo-Young Lee, Sang Yong Song, In-Gu Do, Tae-Joong Kim, Byoung-Gie Kim, Jeong-Won Lee, Duk-Soo Bae
JournalEuropean journal of obstetrics, gynecology, and reproductive biology (Eur J Obstet Gynecol Reprod Biol) Vol. 164 Issue 2 Pg. 180-4 (Oct 2012) ISSN: 1872-7654 [Electronic] Ireland
PMID22959143 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2012 Elsevier Ireland Ltd. All rights reserved.
Chemical References
  • Biomarkers
  • Ki-67 Antigen
  • Neoplasm Proteins
  • Dynamin II
Topics
  • Adult
  • Aged
  • Alphapapillomavirus (isolation & purification)
  • Biomarkers (metabolism)
  • Cervix Uteri (metabolism, pathology, virology)
  • Dynamin II (metabolism)
  • Female
  • Humans
  • Immunohistochemistry
  • Ki-67 Antigen (metabolism)
  • Middle Aged
  • Neoplasm Grading
  • Neoplasm Proteins (metabolism)
  • Neoplasm Staging
  • Papillomavirus Infections (complications, epidemiology, virology)
  • Republic of Korea (epidemiology)
  • Risk
  • Sensitivity and Specificity
  • Uterine Cervical Neoplasms (diagnosis, metabolism, pathology, virology)
  • Uterine Cervical Dysplasia (diagnosis, metabolism, pathology, virology)

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