Abstract | OBJECTIVE: STUDY DESIGN: We performed immunohistochemical stains of dynamin 2 and Ki-67 on tumor samples of patients with CIN and the type of HPV infection was investigated. RESULTS: All the patients with reactive changes (n=7) or normal (n=4) did not show dynamin 2 expression. There were 33, 14, and 12 cases with CIN I, II, and III, respectively, and there was a negative correlation between the degree of dynamin 2 expression and the severity of CIN lesions with statistical significance (P<0.001). Negative expression of dynamin 2 was more sensitive for the detection of CIN II/III than high expression (2+) of Ki-67 (96.2% vs. 73.1%, P=0.041). Among patients in whom HPV infection was detected, the degrees of dynamin 2 expression were not associated with the type of HPV infection (low-risk vs. high-risk). Overall, there was a negative correlation between the expression patterns of Ki-67 and dynamin 2. CONCLUSION: We found that dynamin 2 may be a helpful biomarker in grading of CIN lesions and a candidate biomarker for detecting low grade CIN with high sensitivity.
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Authors | Yoo-Young Lee, Sang Yong Song, In-Gu Do, Tae-Joong Kim, Byoung-Gie Kim, Jeong-Won Lee, Duk-Soo Bae |
Journal | European journal of obstetrics, gynecology, and reproductive biology
(Eur J Obstet Gynecol Reprod Biol)
Vol. 164
Issue 2
Pg. 180-4
(Oct 2012)
ISSN: 1872-7654 [Electronic] Ireland |
PMID | 22959143
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2012 Elsevier Ireland Ltd. All rights reserved. |
Chemical References |
- Biomarkers
- Ki-67 Antigen
- Neoplasm Proteins
- Dynamin II
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Topics |
- Adult
- Aged
- Alphapapillomavirus
(isolation & purification)
- Biomarkers
(metabolism)
- Cervix Uteri
(metabolism, pathology, virology)
- Dynamin II
(metabolism)
- Female
- Humans
- Immunohistochemistry
- Ki-67 Antigen
(metabolism)
- Middle Aged
- Neoplasm Grading
- Neoplasm Proteins
(metabolism)
- Neoplasm Staging
- Papillomavirus Infections
(complications, epidemiology, virology)
- Republic of Korea
(epidemiology)
- Risk
- Sensitivity and Specificity
- Uterine Cervical Neoplasms
(diagnosis, metabolism, pathology, virology)
- Uterine Cervical Dysplasia
(diagnosis, metabolism, pathology, virology)
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