Factor VIIa-antithrombin complexes in patients with non-neoplastic portal vein thrombosis with and without cirrhosis.

Abstract

INTRODUCTION:

Portal vein thrombosis (PVT) is caused by local and systemic prothrombotic risk factors. In this case-control study, we evaluated the use of the Factor VIIa-antithrombin complex (FVIIa-AT) complex assay as a hypercoagulability marker in patients with PVT.

METHODS:

Two different groups of cases were considered: (i) n = 12 noncirrhotic PVT patients, (ii) n = 33 cirrhotic patients with PVT. Controls were sex and age-matched healthy volunteers and cirrhotic subjects without PVT, respectively.

RESULTS:

Levels of the FVIIa-AT complex were significantly higher in noncirrhotic PVT subjects (132 ± 32 pM) than in healthy volunteers (108 ± 18 pM, P = 0.04). No significant difference in FVIIa-AT complexes was seen between cirrhotic patients with (64 ± 20 pM) or without (61 ± 24 pM) PVT. A linear correlation was seen between FVIIa-AT and FVIIa in noncirrhotic PVT subjects. In cirrhotic patients, FVIIa-AT complexes depended on both FVIIa and AT.

CONCLUSION:

These results confirm the utility of the FVIIa-AT assay in identifying the hypercoagulable state of noncirrhotic patients because of a previous thrombotic event.

• Authors: V Rossetto, L Spiezia, M Senzolo, K Rodriguez, S Gavasso, B Woodhams, P Simioni
• Journal: International journal of laboratory hematology (Int J Lab Hematol) Vol. 35 Issue 1 Pg. 101-5 (Feb 2013) ISSN: 1751-553X [Electronic] England
• PMID: 22958499 (Publication Type: Journal Article)
• Copyright: © 2012 Blackwell Publishing Ltd.

Chemical References

• Biomarkers
• Antithrombin III
• Factor VIIa

Topics

• Adult
• Aged
• Antithrombin III (analysis)
• Biomarkers (blood)
• Blood Coagulation
• Case-Control Studies
• Enzyme-Linked Immunosorbent Assay
• Factor VIIa (analysis)
• Female
• Humans
• Liver Cirrhosis (complications)
• Male
• Middle Aged
• Portal Vein (pathology)
• Retrospective Studies
• Thrombophilia (physiopathology)
• Up-Regulation
• Venous Thrombosis (blood, complications, pathology, physiopathology)
• Young Adult