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Do all the patients with gastric parietal cell antibodies have pernicious anemia?

AbstractOBJECTIVE:
This study evaluated whether all the patients with serum gastric parietal cell antibody (GPCA) positivity had pernicious anemia (PA).
MATERIALS AND METHODS:
The blood hemoglobin (Hb), iron, and vitamin B12 concentrations, and mean corpuscular volume (MCV) in 124 GPCA-positive patients were measured and compared with the corresponding data in 124 age- and sex-matched healthy controls. PA was defined by World Health Organization (WHO) as having an Hb concentration < 13 g dl(-1) for men and < 12 g dl(-1) for women, an MCV ≥ 100 fl, and a serum vitamin B12 level < 200 pg ml(-1) .
RESULTS:
We found that 20, 25, and 20 GPCA-positive patients had deficiencies of Hb (men < 13 g dl(-1) , women < 12 g dl(-1) ), iron (<60 μg dl(-1) ), and vitamin B12 (<200 pg ml(-1) ), respectively. Moreover, 16 GPCA-positive patients had abnormally high MCV (≥ 100 fl). GPCA-positive patients had a significantly higher frequency of Hb, iron, or vitamin B12 deficiency and of abnormally high MCV (all P-values < 0.001) than healthy controls. However, only 12.9% of 124 GPCA-positive patients were diagnosed as having PA by the WHO definition.
CONCLUSION:
Only 12.9% of GPCA-positive patients are discovered to have PA by the WHO definition.
AuthorsA Sun, Y P Wang, H P Lin, J S Chia, C P Chiang
JournalOral diseases (Oral Dis) Vol. 19 Issue 4 Pg. 381-6 (May 2013) ISSN: 1601-0825 [Electronic] Denmark
PMID22957902 (Publication Type: Journal Article)
Copyright© 2012 John Wiley & Sons A/S.
Chemical References
  • Antibodies
  • Autoantibodies
  • Hematinics
  • Hemoglobins
  • anti-thyroglobulin
  • Homocysteine
  • Intrinsic Factor
  • Folic Acid
  • Iron
  • Vitamin B 12
Topics
  • Adult
  • Aged
  • Aged, 80 and over
  • Anemia, Pernicious (blood, diagnosis, immunology)
  • Antibodies (blood)
  • Autoantibodies (blood)
  • Case-Control Studies
  • Erythrocyte Indices
  • Female
  • Folic Acid (blood)
  • Hematinics (blood)
  • Hemoglobins (analysis)
  • Homocysteine (blood)
  • Humans
  • Intrinsic Factor (deficiency)
  • Iron (blood)
  • Male
  • Middle Aged
  • Parietal Cells, Gastric (immunology)
  • Sex Factors
  • Vitamin B 12 (blood)
  • World Health Organization
  • Young Adult

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