Tranexamic acid has proven to be an effective treatment for
heavy menstrual bleeding (HMB). It reduces menstrual blood loss (MBL) by 26%-60% and is significantly more effective than placebo, nonsteroidal anti-inflammatory drugs, oral cyclical luteal phase
progestins, or oral
etamsylate, while the
levonorgestrel-releasing intrauterine system reduces MBL more than
tranexamic acid. Other treatments used for HMB are
oral contraceptives,
danazol, and surgical interventions (
endometrial ablation and
hysterectomy). Medical
therapy is usually considered a first-line treatment for idiopathic HMB.
Tranexamic acid significantly improves the quality of life of women treated for HMB. The recommended oral dosage is 3.9-4 g/day for 4-5 days starting from the first day of the menstrual cycle. Adverse effects are few and mainly mild. No evidence exists of an increase in the incidence of thrombotic events associated with its use. An active thromboembolic disease is a
contraindication. In the US, a history of
thrombosis or
thromboembolism, or an intrinsic risk for
thrombosis or
thromboembolism are considered
contraindications as well. This review focuses on the efficacy and safety of
tranexamic acid in the treatment of idiopathic HMB. We searched for medical literature published in English on
tranexamic acid from Ovid Medline, PubMed, and Cinahl. Additional references were identified from the reference lists of articles. Ovid Medline, PubMed, and Cinahl search terms were "
tranexamic acid" and "
menorrhagia" or "
heavy menstrual bleeding." Searches were last updated on March 25, 2012. Studies with women receiving
tranexamic acid for HMB were included; randomized controlled studies with a description of appropriate statistical methodology were preferred. Relevant data on the physiology of menstruation and the pharmacodynamics and pharmacokinetics of
tranexamic acid are also included.