Antibasal Ganglia Antibodies and Antistreptolysin O in Noncomorbid ADHD.

Abstract

OBJECTIVE:

An association between streptococcal infections, ABGA positivity, and no comorbidity ADHD (nc-ADHD) has been little investigated. The aim of this study was to evaluate the streptococcal infection frequency, defined entitled serum antistreptolysin O (ASO), and frequency of serum ABGA positivity in a sample of patients with nc-ADHD.

METHOD:

In all 40 participants were investigated the ASO titer and ABGA.

RESULTS:

The results showed that ABGA positivity was statistically significantly higher in patients affected by ADHD than in patients of a control group, and pathological values of ASO were statistically more frequent in the ADHD group than the control group.

CONCLUSION:

These data suggest that streptococcal infections and autoimmune reactions against the basal ganglia are more frequent in ADHD patients than patients in a control group.

• Authors: Maddalena Toto, Francesco Margari, Marta Simone, Francesco Craig, Maria Giuseppina Petruzzelli, Silvio Tafuri, Lucia Margari
• Journal: Journal of attention disorders (J Atten Disord) Vol. 19 Issue 11 Pg. 965-70 (Nov 2015) ISSN: 1557-1246 [Electronic] United States
• PMID: 22956712 (Publication Type: Journal Article)
• Copyright: © The Author(s) 2012.

Chemical References

• Antibodies, Bacterial
• Autoantibodies
• Biomarkers
• Immunologic Factors
• Antistreptolysin

Topics

• Adolescent
• Antibodies, Bacterial (analysis)
• Antistreptolysin (analysis)
• Attention Deficit Disorder with Hyperactivity (epidemiology, immunology, microbiology)
• Autoantibodies (blood, immunology)
• Basal Ganglia (immunology)
• Biomarkers (analysis, blood)
• Child
• Child, Preschool
• Female
• Humans
• Immunologic Factors
• Male
• Prevalence
• Streptococcal Infections (diagnosis, epidemiology, immunology)