A soy-based product fermented by Enterococcus faecium and Lactobacillus helveticus inhibits the development of murine breast adenocarcinoma.

Abstract

PURPOSE:

Soy and its fermented products are considered functional foods. The study objective was to assess three functional food - a non-fermented soy product (NFP), fermented soy product (FSP), fermented soy product enriched with isoflavones (FI) - in terms of their ability to reduce the development of adenocarcinoma in mice, as well their ability on modulating immune system.

METHODS:

It was observed tumor volume and to verify correlations with the immune system it was measured levels of the cytokines IL-1β and TNF-α produced by macrophages as well as IFN-γ produced by lymphocytes using ELISA test, and nitric oxide production by macrophages using Griess reagent.

RESULTS:

All products showed immunological activity, but FSP showed the most effective tumor containment, resulting in smallest tumor volumes. FI animals expressed larger amounts of nitric oxide and IL-1β and exhibited larger tumor sizes than FSP and NFP animals.

CONCLUSIONS:

The results suggested that the ingestion of FSP was most efficient in tumor containment, possibly due to a positive modulation of the immune system by when Enterococcus faecium and Lactobacillus helveticus are added to the soy product.

• Authors: Fernanda Lopes Kinouchi, Danielle Cardoso Geraldo Maia, Lívia Carolina de Abreu Ribeiro, Marisa Campos Polesi Placeres, Graciela Font de Valdez, Lucas Luis Colombo, Elizeu Antônio Rossi, Iracilda Zeppone Carlos
• Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association (Food Chem Toxicol) Vol. 50 Issue 11 Pg. 4144-8 (Nov 2012) ISSN: 1873-6351 [Electronic] England
• PMID: 22954488 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2012 Elsevier Ltd. All rights reserved.

Chemical References

• Antineoplastic Agents
• Interleukin-1beta
• Tumor Necrosis Factor-alpha
• Nitric Oxide
• Interferon-gamma

Topics

• Adenocarcinoma (diet therapy, immunology, metabolism)
• Animals
• Antineoplastic Agents (pharmacology)
• Breast Neoplasms (diet therapy, immunology, metabolism)
• Enterococcus faecium
• Female
• Fermentation
• Interferon-gamma (metabolism)
• Interleukin-1beta (metabolism)
• Lactobacillus helveticus
• Mice
• Mice, Inbred BALB C
• Nitric Oxide (metabolism)
• Soybeans (microbiology)
• Tumor Necrosis Factor-alpha (metabolism)