[Demyelinating polyneuropathies in patients with diabetes mellitus and chronic alcoholic intoxication].

Abstract

Frequency and nosological attribution of demyelinating polyneuropathies in patients with diabetes mellitus and alcoholism were determined. Eighty-six inpatients with alcoholic (n=46) and diabetic (n=40) polyneuropathy were examined clinically and using electroneuromyography (ENMG). A demyelinating pathogenetic variant was identified by clinical and ENMG data in 27 (31%) patients. Nine patients (33%) had dysimmune polyneuropathies (acute and chronic inflammatory demyelinating polyneuropathy). Polyneuropathies were specified as toxic/metabolic with the prevalence of a demyelinating component within the main disease in 18 (67%) patients. Clinical and ENMG-signs of the demyelinating variant of alcoholic and diabetic neuropathy are presented. The efficacy of the antioxidant berlition was shown for toxic/metabolic polyneuropathies while the addition of immune modulators was needed for treatment of dysimmune polyneuropathy.

• Authors: E A Kovrazhkina
• Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova (Zh Nevrol Psikhiatr Im S S Korsakova) Vol. 112 Issue 5 Pg. 41-5 ( 2012) ISSN: 1997-7298 [Print] Russia (Federation)
• PMID: 22951780 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antioxidants
• Thioctic Acid
• berlition

Topics

• Acute Disease
• Alcoholism (complications)
• Antioxidants (therapeutic use)
• Diabetic Nephropathies (classification, diagnosis, drug therapy, etiology)
• Electromyography
• Humans
• Polyneuropathies (classification, diagnosis, drug therapy, etiology)
• Polyradiculoneuropathy, Chronic Inflammatory Demyelinating (classification, diagnosis, drug therapy, etiology)
• Thioctic Acid (therapeutic use)