Omega-3 fatty acid-derived mediator, Resolvin E1, ameliorates 2,4-dinitrofluorobenzene-induced atopic dermatitis in NC/Nga mice.

Abstract

Atopic dermatitis (AD) is a common inflammatory skin disease for which few effective treatments are available. Resolvin E1 (RvE1; 5S,12R,18R-trihydroxy-6Z,8E,10E,14Z,16E-eicosapentaenoic acid) is an endogenous lipid mediator derived from omega-3 fatty eicosapentaenoic acid, which is a potent inhibitor of inflammation. AD-like skin lesion was induced by repetitive skin contact with DNFB in NC/Nga mice and the effects of RvE1 were evaluated on the basis of histopathological findings of skin, ear swelling and cytokine production of CD4(+) T cells. Intraperitoneal injection of RvE1 for one week after DNFB challenge significantly lowered ear swelling and improved back skin lesions. In addition, RvE1 significantly suppressed production of interferon-gamma (IFN-γ) and interleukin-4 (IL-4) by activated CD4(+) T cells and serum IgE level. Furthermore, RvE1 reduced DNFB-induced infiltration of eosinophils, mast cells, CD4(+) T cells, and CD8(+) T cells in skin lesions. Therefore, RvE1 may suppress the development of AD-like skin lesions in DNFB-treated NC/Nga mice by reducing IL-4 and IFN-γ of activated CD4(+) T cells and serum IgE levels and infiltration of immune cells to skin lesion.

• Authors: Tae-Ho Kim, Gun-Dong Kim, Young-Ho Jin, Yong Seek Park, Cheung-Seog Park
• Journal: International immunopharmacology (Int Immunopharmacol) Vol. 14 Issue 4 Pg. 384-91 (Dec 2012) ISSN: 1878-1705 [Electronic] Netherlands
• PMID: 22951188 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2012 Elsevier B.V. All rights reserved.

Chemical References

• Fatty Acids, Omega-3
• Interleukin-4
• Immunoglobulin E
• Interferon-gamma
• Eicosapentaenoic Acid
• Dinitrofluorobenzene
• 5S,12R,18R-trihydroxy-6Z,8E,10E,14Z,16E-eicosapentaenoic acid

Topics

• Animals
• CD4-Positive T-Lymphocytes (metabolism)
• Dermatitis, Atopic (chemically induced, drug therapy)
• Dinitrofluorobenzene (toxicity)
• Dose-Response Relationship, Drug
• Eicosapentaenoic Acid (analogs & derivatives, chemistry, pharmacology)
• Fatty Acids, Omega-3 (chemistry)
• Immunoglobulin E (blood)
• Interferon-gamma (genetics, metabolism)
• Interleukin-4 (genetics, metabolism)
• Male
• Mice
• Mice, Inbred Strains
• Skin (pathology)