Resuscitation with polymerized human placenta hemoglobin attenuated hemorrhagic shock-induced lung injury.

Abstract

This study was designed to investigate whether polymerized human placenta hemoglobin (PolyPHb) attenuated hemorrhagic shock-induced lung injury. A mean arterial pressure (MAP) of 30mmHg was maintained for 60 min. Then, all the rats were randomly resuscitated with hetastarch, whole blood, or PolyPHb. The result indicated that PolyPHb greatly improved the MAP and pulmonary function, and significantly reduced the release of inflammatory cytokines, histopathological changes, and pulmonary edema. Therefore, our findings suggest that PolyPHb could reduce pulmonary injury after hemorrhagic shock, and this effect was probably associated with the depressed inflammatory response.

• Authors: Tao Li, Zhenyu Zhang, Wei Wu, Daqin Liao, Yanfang Chen, Shen Li, Chengmin Yang, Xuewen Xu, Jin Liu
• Journal: Artificial cells, nanomedicine, and biotechnology (Artif Cells Nanomed Biotechnol) Vol. 41 Issue 1 Pg. 27-31 (Feb 2013) ISSN: 2169-141X [Electronic] England
• PMID: 22947048 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Cytokines
• Hemoglobins
• Inflammation Mediators

Topics

• Animals
• Arterial Pressure (drug effects)
• Cytokines (metabolism)
• Female
• Hemoglobins (administration & dosage, chemical synthesis, metabolism)
• Humans
• Inflammation Mediators (metabolism)
• Lung (drug effects, immunology, pathology)
• Lung Injury (etiology, immunology, prevention & control)
• Male
• Placenta (metabolism)
• Polymerization
• Pregnancy
• Pulmonary Edema (etiology, immunology, prevention & control)
• Rats
• Rats, Sprague-Dawley
• Respiratory Function Tests
• Resuscitation
• Shock, Hemorrhagic (complications, drug therapy, immunology)