Clinical significance of MMP-7 and PTEN expression in colorectal cancer.

Abstract

BACKGROUND/AIMS:

The aim of this study was to investigate the expression of MMP-7 and PTEN protein in colorectal cancer and explore its correlation with clinicopathological parameters.

METHODOLOGY:

In colorectal cancer tissue samples (n=48) and normal rectal tissue samples (n=23), the expression of MMP-7 and PTEN was detected by immunohistochemistry. Using medical records, the relationship of MMP-7 and PTEN expression with clinicopathological parameters was analyzed.

RESULTS:

Compared to normal rectal tissue, MMP-7 expression was significantly higher in all grades of colorectal cancer. In contrast, PTEN expression was significantly lower than levels in normal rectal tissue. There was significant negative correlation between MMP-7 and PTEN expression in colorectal cancer (r=-0.403, p>0.05). MMP-7 and PTEN expression in colorectal cancer samples was correlated with differentiation, lymph node metastasis, serosa infiltration, and Duke's stage (p<0.05) but not with gender, age, or tumor size (p>0.05).

CONCLUSIONS:

Reduced PTEN expression and MMP-7 over-expression may play important roles in the pathogenesis of colorectal cancer. Combined detection may provide prognostic benefit towards colorectal cancer.

• Authors: Zheng Bi, Lai-Dong Dong, Xiao-Meng Gu
• Journal: Hepato-gastroenterology (Hepatogastroenterology) 2013 Jan-Feb Vol. 60 Issue 121 Pg. 32-6 ISSN: 0172-6390 [Print] Greece
• PMID: 22944341 (Publication Type: Journal Article)

Chemical References

• PTEN Phosphohydrolase
• PTEN protein, human
• MMP7 protein, human
• Matrix Metalloproteinase 7

Topics

• Aged
• Colorectal Neoplasms (chemistry, etiology, pathology)
• Female
• Humans
• Immunohistochemistry
• Lymphatic Metastasis
• Male
• Matrix Metalloproteinase 7 (analysis, physiology)
• Middle Aged
• Neoplasm Staging
• PTEN Phosphohydrolase (analysis, physiology)