Comparison of the cytotoxic effects of enantiopure PPAPs, including nemorosone and clusianone.

Abstract

The synthesis of an unnatural polyprenylated acylphloroglucinol (PPAP), regioisomeric with nemorosone and clusianone, has been accomplished. The separated enantiomers of this new PPAP, along with those of nemorosone and clusianone, have been screened for activity against HeLa (cervix carcinoma), MIA-PaCa-2 (pancreatic carcinoma), and MCF7 (mamma carcinoma) cancer cell lines. All of the isomers examined gave surprisingly similar results in the screens.

• Authors: Nigel S Simpkins, Frank Holtrup, Vincent Rodeschini, James D Taylor, Robert Wolf
• Journal: Bioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 22 Issue 19 Pg. 6144-7 (Oct 01 2012) ISSN: 1464-3405 [Electronic] England
• PMID: 22944119 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2012 Elsevier Ltd. All rights reserved.

Chemical References

• 7-epiclusianone
• Antineoplastic Agents
• Benzophenones
• Benzoquinones
• Bridged Bicyclo Compounds
• nemorosone

Topics

• Antineoplastic Agents (chemical synthesis, chemistry, pharmacology)
• Benzophenones (chemical synthesis, chemistry, pharmacology)
• Benzoquinones
• Bridged Bicyclo Compounds (chemical synthesis, chemistry, pharmacology)
• Cell Line, Tumor
• Dose-Response Relationship, Drug
• Drug Screening Assays, Antitumor
• HeLa Cells
• Humans
• MCF-7 Cells
• Molecular Conformation
• Stereoisomerism
• Structure-Activity Relationship