Systematized epidermal nevus with epidermolytic hyperkeratosis improving with topical calcipotriol/betametasone dipropionate combination ointment.

Abstract

We present the case of a 5-year-old boy who presented with systematized epidermal nevus with evidence of epidermolytic hyperkeratosis on skin biopsy. He was otherwise well, with normal growth and development and no evidence of other organ system involvement. He had experienced only mild improvement with potent topical corticosteroids. He reported more-marked improvement after 2 months of topical calcipotriol/betamethasone dipropionate combination ointment once a day to the lesions. Extensive epidermal nevi can lead to severe cosmetic disfigurement. We recommend a trial of topical calcipotriol/betamethasone dipropionate ointment for patients with extensive epidermal nevus not amenable to surgical treatment.

• Authors: Mark Jean-Aan Koh, Joyce Siong-See Lee, Wei-Sheng Chong
• Journal: Pediatric dermatology (Pediatr Dermatol) 2013 May-Jun Vol. 30 Issue 3 Pg. 370-3 ISSN: 1525-1470 [Electronic] United States
• PMID: 22938157 (Publication Type: Case Reports, Journal Article)
• Copyright: © 2012 Wiley Periodicals, Inc.

Chemical References

• Anti-Inflammatory Agents
• Dermatologic Agents
• Ointments
• calcipotriene
• betamethasone-17,21-dipropionate
• Betamethasone
• Calcitriol

Topics

• Administration, Topical
• Anti-Inflammatory Agents (administration & dosage)
• Betamethasone (administration & dosage, analogs & derivatives)
• Calcitriol (administration & dosage, analogs & derivatives)
• Child, Preschool
• Dermatologic Agents (administration & dosage)
• Humans
• Hyperkeratosis, Epidermolytic (complications, drug therapy, pathology)
• Male
• Nevus (complications, drug therapy, pathology)
• Ointments (administration & dosage)
• Skin Neoplasms (complications, drug therapy, pathology)
• Treatment Outcome