Screen anti-influenza lead compounds that target the PA(C) subunit of H5N1 viral RNA polymerase.

The avian influenza (H5N1) viral RNA polymerase protein PA(C) was used as a target to screen nine chlorogenic acid derivatives for their polymerase inhibitor activity. Among them, seven compounds were PA(C) ligands, and four inhibited influenza RNA polymerase activity. These results aid in the design of anti-influenza agents based on caffeoylquinic acid.
AuthorsLin Li, Shenghai Chang, Junfeng Xiang, Qian Li, Huanhuan Liang, Yalin Tang, Yingfang Liu
JournalPloS one (PLoS One) Vol. 7 Issue 8 Pg. e35234 ( 2012) ISSN: 1932-6203 [Electronic] United States
PMID22936968 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antiviral Agents
  • Viral Proteins
  • caffeoylquinic acid
  • Quinic Acid
  • DNA-Directed RNA Polymerases
  • Antiviral Agents (chemistry, pharmacology)
  • DNA-Directed RNA Polymerases (antagonists & inhibitors)
  • Drug Design
  • Drug Evaluation, Preclinical
  • Humans
  • Influenza A Virus, H5N1 Subtype (enzymology)
  • Magnetic Resonance Spectroscopy
  • Quinic Acid (analogs & derivatives, chemistry)
  • Viral Proteins (antagonists & inhibitors)

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