Combined intra-arterial infusion and systemic chemoradiotherapy for stage IV squamous cell carcinoma of the mandibular gingiva.

Abstract

PURPOSE:

The purpose of this study was to show the effectiveness of combining intra-arterial infusion and systemic chemotherapy with concurrent radiotherapy for treatment of stage IV mandibular gingival cancer.

MATERIALS AND METHODS:

A total of 23 patients with mandibular gingival cancer were treated with either docetaxel by intra-arterial infusion followed by systemic chemoradiotherapy with cisplatinum and 5-fluorouracil as a monthly regimen, or with docetaxel and cisplatinum by intra-arterial infusion followed by systemic chemoradiotherapy with 5-fluorouracil as a weekly or biweekly regimen. Tumor responses, locoregional control, overall survival, disease-specific survival, and adverse events were evaluated.

RESULTS:

Of the 23 patients enrolled in the study, 22 completed the treatment. With regard to clinical stages, 82 % were diagnosed as IVA and 18 % IVB. Complete and partial response was observed in 82 and 18 %, respectively. Five-year overall survival, disease-specific survival, and locoregional control were 51, 70, and 72 %, respectively. No statistically significant difference was seen between the monthly regimen and the weekly plus biweekly regimen, although the latter resulted in longer survival and 88 % control.

CONCLUSION:

Combined intra-arterial infusion and systemic chemoradiotherapy may be an effective treatment for patients with stage IV mandibular gingival cancer.

• Authors: Tatsuhiko Nakasato, Mitsuru Izumisawa, Akio Akahane, Koyo Kikuchi, Shigeru Ehara, Satoru Shoji, Shintaro Kogi, Harumi Mizuki, Yoshiki Sugiyama
• Journal: Japanese journal of radiology (Jpn J Radiol) Vol. 30 Issue 9 Pg. 752-61 (Nov 2012) ISSN: 1867-108X [Electronic] Japan
• PMID: 22936237 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents
• Taxoids
• Docetaxel
• Cisplatin
• Fluorouracil

Topics

• Aged
• Aged, 80 and over
• Antineoplastic Agents (administration & dosage)
• Carcinoma, Squamous Cell (therapy)
• Chemoradiotherapy
• Cisplatin (administration & dosage)
• Combined Modality Therapy
• Docetaxel
• Drug Administration Schedule
• Female
• Fluorouracil (administration & dosage)
• Gingival Neoplasms (therapy)
• Humans
• Infusions, Intra-Arterial
• Male
• Mandible
• Middle Aged
• Taxoids (administration & dosage)
• Treatment Outcome