Abstract | BACKGROUND: The aim of this study was to evaluate the association between clinical signs of congenital toxoplasmosis and IgG subclasses found in newborns participating in the Minas Gerais State Neonatal Screening Program. METHODS: RESULTS: Newborns with congenital toxoplasmosis but without ocular lesions were more likely to present anti-rMIC3 total IgG when compared with those newborns with active or cicatricial retinochoroidal lesions. Detection of anti-rMIC3 IgG2 and IgG4 was associated with presence of retinochoroidal lesions and intracranial calcifications, with higher mean reactivity index values than unaffected newborns with congenital toxoplasmosis. Anti-STAg IgG3 was associated with newborns without neurologic damage. CONCLUSIONS:
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Authors | Carlos Henryque de Souza-e-Silva, Daniel Vitor Vasconcelos-Santos, Gláucia Queiroz de Andrade, Ericka Viana Machado Carellos, Roberta Maia de Castro Romanelli, Luciana Macedo de Resende, José Nélio Januário, Mariangela Carneiro, Ana Carolina de Aguiar Vasconcelos Carneiro, Ricardo Wagner de Almeida Vitor |
Journal | The Pediatric infectious disease journal
(Pediatr Infect Dis J)
Vol. 32
Issue 1
Pg. 13-6
(Jan 2013)
ISSN: 1532-0987 [Electronic] United States |
PMID | 22935868
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antibodies, Protozoan
- Antigens, Protozoan
- Biomarkers
- Immunoglobulin G
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Topics |
- Antibodies, Protozoan
(blood, classification, immunology)
- Antigens, Protozoan
(immunology)
- Biomarkers
(blood)
- Brazil
(epidemiology)
- Chi-Square Distribution
- Enzyme-Linked Immunosorbent Assay
- Humans
- Immunoglobulin G
(blood, classification, immunology)
- Infant
- Infant, Newborn
- Toxoplasma
(immunology)
- Toxoplasmosis, Congenital
(blood, epidemiology, immunology)
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