Abstract | OBJECTIVES: METHODS: We assessed the associations of the National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATPIII) defined MetS and its criteria with high resolution B-mode ultrasound determined common carotid artery intima-media thickness (cIMT) and carotid artery plaque in multivariable regression models in 104 black and 93 Caucasian women with RA. RESULTS: The MetS prevalence was 30.8% in black compared to 9.7% in Caucasian women with RA (adjusted odds ratio [95% confidence interval]=10.11 [1.76-58.03] [p=0.009]). Population origin impacted on the relationships of metabolic risk factors with atherosclerosis. In Caucasian women, the MetS was associated with cIMT (p=0.036) and MetS triglycerides and the number of MetS criteria were each associated with both cIMT (p=0.01 and p=0.028, respectively) and plaque (p=0.049 and p=0.02, respectively); by contrast, in black women, MetS blood pressure was related to cIMT (p=0.04). CONCLUSIONS: A high overall metabolic cardiovascular risk burden as disclosed by markedly prevalent MetS in women with RA from developing groups of black African descent was not associated with atherosclerosis. This calls for systematic rigorous cardiovascular risk management irrespective of metabolic risk factor profiles in African black women with RA.
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Authors | Patrick H Dessein, Gavin R Norton, Barry I Joffe, Abu T Abdool-Carrim, Angela J Woodiwiss, Ahmed Solomon |
Journal | Clinical and experimental rheumatology
(Clin Exp Rheumatol)
2013 Jan-Feb
Vol. 31
Issue 1
Pg. 53-61
ISSN: 0392-856X [Print] Italy |
PMID | 22935383
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Topics |
- Arthritis, Rheumatoid
(diagnosis, ethnology, physiopathology)
- Black People
(statistics & numerical data)
- Blood Pressure
- Carotid Artery Diseases
(diagnosis, ethnology, physiopathology)
- Carotid Intima-Media Thickness
- Cross-Sectional Studies
- Developing Countries
- Female
- Humans
- Linear Models
- Logistic Models
- Metabolic Syndrome
(diagnosis, ethnology, physiopathology)
- Multivariate Analysis
- Odds Ratio
- Predictive Value of Tests
- Prevalence
- Risk Assessment
- Risk Factors
- Sex Factors
- South Africa
(epidemiology)
- White People
(statistics & numerical data)
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