Abstract |
Caveolae and caveolin are key players in a number of disease processes. Current research indicates that caveolins play a significant role in cardiovascular disease and dysfunction. The far-reaching roles of caveolins in disease and dysfunction make them particularly notable therapeutic targets. In particular, caveolin-1 (Cav-1) and caveolin-3 (Cav-3) have been identified as potential regulators of vascular dysfunction and heart disease and might even confer cardiac protection in certain settings. Such a central role in vascular health therefore makes manipulation of Cav-1/3 function or expression levels clear therapeutic targets in a variety of cardiovascular related disease states. Here, we highlight the role of Cav-1 and Cav-3 in cardiovascular health and explore the potential of Cav-1 and Cav-3 derived experimental therapeutics.
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Authors | Stephanie L Sellers, Andy E Trane, Pascal N Bernatchez |
Journal | Frontiers in physiology
(Front Physiol)
Vol. 3
Pg. 280
( 2012)
ISSN: 1664-042X [Electronic] Switzerland |
PMID | 22934034
(Publication Type: Journal Article)
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