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Otitis media and otomastoiditis caused by Mycobacterium massiliense (Mycobacterium abscessus subsp. bolletii).

Abstract
We describe two patients with otologic infections caused by Mycobacterium massiliense (M. abscessus subsp. bolletti) which were identified using erm(41) PCR, 23S rRNA, and rpoB gene sequence analysis. They were middle-aged adults with underlying otologic diseases and were treated successfully with clarithromycin-based combination regimens for 3 and 9 months, respectively.
AuthorsMeng-Rui Lee, Hsih-Yeh Tsai, Aristine Cheng, Chia-Ying Liu, Yu-Tsung Huang, Chun-Hsing Liao, Sheng-Kai Liang, Li-Na Lee, Po-Ren Hsueh
JournalJournal of clinical microbiology (J Clin Microbiol) Vol. 50 Issue 11 Pg. 3754-6 (Nov 2012) ISSN: 1098-660X [Electronic] United States
PMID22933592 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Anti-Bacterial Agents
  • DNA, Bacterial
  • DNA, Ribosomal
  • RNA, Ribosomal, 23S
  • Methyltransferases
  • DNA-Directed RNA Polymerases
  • RNA polymerase beta subunit
  • Clarithromycin
Topics
  • Anti-Bacterial Agents (administration & dosage)
  • Clarithromycin (administration & dosage)
  • DNA, Bacterial (chemistry, genetics)
  • DNA, Ribosomal (chemistry, genetics)
  • DNA-Directed RNA Polymerases (genetics)
  • Drug Therapy, Combination (methods)
  • Humans
  • Male
  • Mastoiditis (drug therapy, microbiology)
  • Methyltransferases (genetics)
  • Microbial Sensitivity Tests
  • Middle Aged
  • Mycobacterium (classification, drug effects, genetics, isolation & purification)
  • Mycobacterium Infections (diagnosis, drug therapy, microbiology)
  • Otitis Media (drug therapy, microbiology)
  • RNA, Ribosomal, 23S (genetics)
  • Sequence Analysis, DNA
  • Treatment Outcome

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