Abstract | OBJECTIVE: To investigate the clinical feature, treatment, and prognosis of hospitalized patients with jaw osteoradionecrosis. METHODS: A total of 93 cases with jaw osteoradionecrosis treated between 2000 and 2010 was reviewed. Of the 93 cases, 79 cases were with mandible lesions, 13 cases with maxillary lesions, and 1 case with both mandible and maxillary lesions. Sixty-six cases received one course of radiotherapy, with the radiation doses of 34 - 90 Gy (mean 64.6 Gy). Twenty-two cases experienced tooth extraction or other operative procedures before exhibition of the clinical symptoms for osteoradionecrosis. The interval time between radiotherapy and the onset of osteoradionecrosis varied from 2 weeks to 32 years (mean 54 months). RESULTS: Of 93 cases, 56 patients underwent radical resection of the pathologic bone and reconstruction with free tissue flaps, in whom 7 cases received the second surgery due to microvascular thrombosis in flap vessels, and flaps were survival by new vascular anastomosis in 3 cases, the failed flaps were removed and replaced successfully by non vascularized bone grafts in 2 cases, and the failed flaps removed and the defects were repaired with adjacent skin in other 2 cases. In the 56 cases, only one case was with disease recurrence and 53 cases with significant improvement in chewing and swallowing functions. Only 2 of 93 cases underwent resection of the pathologic bone and reconstruction with titanium plates, and thereafter they encountered titanium exposure. Scaling of osteoradionecrosis lesions was applied to 20 of 93 patients and 9 cases of them were with disease recurrence. Fifteen cases had resection of the effected mandible without reconstruction. Disease relapse was encountered in 2 of them, others had poor chewing and swallowing. CONCLUSIONS:
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Authors | Ru-huang Li, Zhi-gang Cai, Chi Mao, Chuan-bin Guo, Jian-guo Zhang, Yi Zhang, Jie Zhang |
Journal | Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
(Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi)
Vol. 47
Issue 6
Pg. 458-61
(Jun 2012)
ISSN: 1673-0860 [Print] China |
PMID | 22932136
(Publication Type: Journal Article)
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Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Bone Plates
- Child
- Female
- Humans
- Jaw
(pathology)
- Male
- Mandible
(pathology)
- Middle Aged
- Orthognathic Surgical Procedures
- Osteoradionecrosis
(diagnosis, surgery)
- Plastic Surgery Procedures
(methods)
- Retrospective Studies
- Surgical Flaps
- Young Adult
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