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[Ertapenem administered intravenously or subcutaneously for urinary tract infections caused by ESBL producing enterobacteriacea].

AbstractINTRODUCTION:
Ertapenem could be used to treat urinary tract infections (UTI) caused by ESBL producing enterobacteriacae (ESBL-E) and administered subcutaneously.
METHOD:
The authors made a retrospective study on adult patients treated with ertapenem administered intravenously or subcutaneously for UTI caused by ESBL-E, between May 2009 and August 2011 at the Chambery hospital, France.
RESULTS:
Twenty-five patients were treated (13 cases of prostatitis, ten of pyelonephritis, two of cystitis) mostly caused by Escherichia coli (24 cases). Subcutaneous injections were administered to 20 patients and 23 were treated through outpatient parenteral antibiotic therapy (OPAT). All patients were cured at the end of the ertapenem therapy. Urine samples collected during treatment for 12 patients were sterile. Three months after the end of the treatment, five patients had relapsed, and six had developed a UTI caused by another bacteria.
CONCLUSION:
Ertapenem administered intravenously or subcutaneously could be an effective treatment for UTI caused by ESBL-E, especially using OPAT.
AuthorsE Forestier, S Gros, D Peynaud, M Levast, D Boisseau, C Ferry-Blanco, A Labe, C Lecomte, O Rogeaux
JournalMedecine et maladies infectieuses (Med Mal Infect) Vol. 42 Issue 9 Pg. 440-3 (Sep 2012) ISSN: 1769-6690 [Electronic] France
Vernacular TitleErtapénem intraveineux ou sous-cutané pour le traitement des infections urinaires à entérobactérie sécrétrice de BLSE.
PMID22925551 (Publication Type: Journal Article)
CopyrightCopyright © 2012 Elsevier Masson SAS. All rights reserved.
Chemical References
  • Escherichia coli Proteins
  • beta-Lactams
  • beta-Lactamases
  • Ertapenem
Topics
  • Adult
  • Aged
  • Aged, 80 and over
  • Ambulatory Care
  • Cystitis (drug therapy, microbiology)
  • Drug Evaluation
  • Ertapenem
  • Escherichia coli (drug effects, enzymology)
  • Escherichia coli Infections (drug therapy, microbiology)
  • Escherichia coli Proteins (analysis)
  • Female
  • Humans
  • Injections, Intravenous
  • Injections, Subcutaneous
  • Klebsiella Infections (drug therapy, microbiology)
  • Klebsiella pneumoniae (drug effects, enzymology, isolation & purification)
  • Male
  • Middle Aged
  • Prostatitis (drug therapy, microbiology)
  • Pyelonephritis (drug therapy, microbiology)
  • Recurrence
  • Retrospective Studies
  • Risk Factors
  • beta-Lactam Resistance
  • beta-Lactamases (analysis)
  • beta-Lactams (administration & dosage, therapeutic use)

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