miR-183 inhibits the metastasis of osteosarcoma via downregulation of the expression of Ezrin in F5M2 cells.

Abstract

Osteosarcoma is the most common primary malignancy of bone in teenagers and approximately 30% of patients develop lung metastasis, which is the leading cause of mortality. Recent studies suggest that the Ezrin protein is correlated with the metastatic potential of several malignant tumors. In our study, ectopic overexpression of miR-183 repressed the expression levels of Ezrin and significantly inhibited the motility and invasion of osteosarcoma cells. This suggests that miR-183 may possibly play a tumor suppressor role in the metastasis of osteosarcoma by downregulating Ezrin expression levels. These findings show that through inhibition of Ezrin expression levels, miR-183 is significantly involved in cell migration and invasion of osteosarcoma.

• Authors: Haien Zhao, Mingjun Guo, Guangyi Zhao, Qiong Ma, Baoan Ma, Xiuchun Qiu, Qingyu Fan
• Journal: International journal of molecular medicine (Int J Mol Med) Vol. 30 Issue 5 Pg. 1013-20 (Nov 2012) ISSN: 1791-244X [Electronic] Greece
• PMID: 22922800 (Publication Type: Journal Article)

Chemical References

• Cytoskeletal Proteins
• MIRN183 microRNA, human
• MicroRNAs
• ezrin

Topics

• Apoptosis
• Bone Neoplasms (metabolism, pathology)
• Cell Line, Tumor
• Cell Movement
• Cytoskeletal Proteins (genetics, metabolism)
• Down-Regulation
• Gene Expression
• Humans
• MicroRNAs (genetics, metabolism, physiology)
• Neoplasm Invasiveness
• Osteosarcoma (metabolism, secondary)
• RNA Interference