Serum of Babesia rodhaini infected mice down regulates catalase activity of healthy erythrocytes.

Abstract

Hemolytic activity for animals infected with various Babesia species is well reported. In this study, we confirmed that serum of Babesia rodhaini-infected mice also showed hemolytic activity. Erythrocytes from non-infected mice were lysed by co-incubation with B. rodhaini-infected serum. Catalase activity of the non-infected target erythrocytes was suppressed after this co-incubation with the hemolytic serum of B. rodhaini-infected mice. Furthermore, serum hemolytic activity was inhibited when target erythrocytes were incubated with hemolytic serum in the presence of exogenous catalase. Our study indicated that hemolytic serum can down-regulate the antioxidant capacity of non-infected healthy erythrocytes, possibly as a result of catalase activity, thereby leading to hemolysis.

• Authors: Shih-Pin Chiou, Naoaki Yokoyama, Ikuo Igarashi, Katsuya Kitoh, Yasuhiro Takashima
• Journal: Experimental parasitology (Exp Parasitol) Vol. 132 Issue 3 Pg. 327-33 (Nov 2012) ISSN: 1090-2449 [Electronic] United States
• PMID: 22921498 (Publication Type: Journal Article)
• Copyright: Copyright © 2012 Elsevier Inc. All rights reserved.

Chemical References

• Autoantibodies
• Reactive Oxygen Species
• Superoxides
• Catalase

Topics

• Animals
• Autoantibodies (blood)
• Babesia (immunology)
• Babesiosis (blood, immunology)
• Catalase (metabolism)
• Down-Regulation (immunology)
• Erythrocytes (enzymology, immunology)
• Female
• Hemolysis (immunology)
• Leukocytes (metabolism)
• Mice
• Mice, Inbred C57BL
• Oxidation-Reduction
• Reactive Oxygen Species (metabolism)
• Superoxides (blood)