[Could antifungal lock be useful in the management of candidiasis linked with catheters?].

Abstract

Fungal biofilms associated with inserted medical devices such as catheters, represent a major risk factor for candidemia. In addition, these biofilm yeasts show a decreased susceptibility to antifungal agents. Recently, a new therapeutic approach has emerged, the "lock therapy", based on the use of high concentrations of antimicrobials, instilled into the lumen of the catheter and left in place for 8 to 12 h. In vitro or in vivo studies have evaluated the interest of antifungal locks using amphotericin B, an azole or echinocandins. The promising results will permit us to discuss the relevance of this technique.

• Authors: Estelle Cateau, Marie-Hélène Rodier, Christine Imbert
• Journal: Medecine sciences : M/S (Med Sci (Paris)) 2012 Aug-Sep Vol. 28 Issue 8-9 Pg. 740-5 ISSN: 0767-0974 [Print] France
• Vernacular Title: Candidoses associées aux cathéters : quelle place pour les verrous antifongiques?
• PMID: 22920876 (Publication Type: Journal Article, Review)
• Copyright: © 2012 médecine/sciences – Inserm / SRMS.

Chemical References

• Antifungal Agents
• Echinocandins
• Lipopeptides
• liposomal amphotericin B
• Amphotericin B
• Caspofungin
• Micafungin

Topics

• Amphotericin B (administration & dosage, therapeutic use)
• Antifungal Agents (administration & dosage, therapeutic use)
• Biofilms (drug effects)
• Candida (drug effects, physiology)
• Candidemia (drug therapy, etiology, prevention & control)
• Caspofungin
• Catheter-Related Infections (drug therapy, prevention & control)
• Dose-Response Relationship, Drug
• Drug Resistance, Fungal
• Echinocandins (administration & dosage, therapeutic use)
• Humans
• Lipopeptides (administration & dosage, therapeutic use)
• Micafungin