HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Cellular and physiological effects of anthrax exotoxin and its relevance to disease.

Abstract
Bacillus anthracis, the causative agent of anthrax, secretes a tri-partite exotoxin that exerts pleiotropic effects on the host. The purification of the exotoxin components, protective antigen, lethal factor, and edema factor allowed the rapid characterization of their physiologic effects on the host. As molecular biology matured, interest focused on the molecular mechanisms and cellular alterations induced by intoxication. Only recently have researchers begun to connect molecular and cellular knowledge back to the broader physiological effects of the exotoxin. This review focuses on the progress that has been made bridging molecular knowledge back to the exotoxin's physiological effects on the host.
AuthorsDavid E Lowe, Ian J Glomski
JournalFrontiers in cellular and infection microbiology (Front Cell Infect Microbiol) Vol. 2 Pg. 76 ( 2012) ISSN: 2235-2988 [Electronic] Switzerland
PMID22919667 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Review)
Chemical References
  • Antigens, Bacterial
  • Bacterial Toxins
  • Virulence Factors
  • anthrax toxin
Topics
  • Animals
  • Anthrax (pathology)
  • Antigens, Bacterial (metabolism)
  • Bacillus anthracis (pathogenicity)
  • Bacterial Toxins (metabolism)
  • Humans
  • Virulence Factors (metabolism)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: