High uptake of (68)Ga-DOTATOC in spleen as compared to splenosis: measurement by PET/CT.

Abstract

AIM:

The aim of this study is to ascertain the high somatostatin receptor (SSTR) uptake in spleen and to compare the uptake in spleen and splenosis using SSTR PET/CT using( 68)Ga-DOTATOC.

MATERIALS AND METHODS:

SUV(max) of spleen on (68)Ga-DOTATOC SSTR PET/CT (acquired for initial staging) in 10 patients with known neuroendocrine neoplasm of pancreatic tail was analyzed. All patients underwent left pancreatectomy and splenectomy. Diagnosis of splenosis was confirmed on CT, and SUV(max) was noted on follow-up SSTR PET/CT.

RESULTS:

SUV(max)was 28.8 ± 12.5 in normal spleen and 10.5 ± 4.3 in splenosis.

CONCLUSION:

The high uptake of( 68)Ga-DOTATOC (which has a high affinity to SSTR 2) in the spleen as compared to splenosis, which has a different histology, suggests white pulp as the probable site of high SSTR 2 expression.

• Authors: Harshad R Kulkarni, Vikas Prasad, Daniel Kaemmerer, Merten Hommann, Richard P Baum
• Journal: Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer (Recent Results Cancer Res) Vol. 194 Pg. 373-8 ( 2013) ISSN: 0080-0015 [Print] Germany
• PMID: 22918769 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Gallium Radioisotopes
• Radiopharmaceuticals
• Octreotide
• Edotreotide

Topics

• Aged
• Female
• Gallium Radioisotopes (pharmacokinetics)
• Humans
• Male
• Middle Aged
• Multimodal Imaging (methods)
• Octreotide (analogs & derivatives, pharmacokinetics)
• Positron-Emission Tomography
• Radiopharmaceuticals (pharmacokinetics)
• Spleen (metabolism)
• Splenosis (diagnostic imaging)
• Tomography, X-Ray Computed