Murine anti-tumor activity of new water soluble platinum(II) complexes with reduced toxicity.

A series of new water soluble sugar and non-sugar containing platinum(II) complexes was synthesized and evaluated for effects of the sugar moiety on water solubility, anti-tumor activity, and acute leukopenia. When tested in vivo against the murine P388 and L1210 leukemias at LD10/maximally effective doses, the compound cis-[(gluconylamino)malonato-O,O'](1R,2R-cyclohexanediami ne-N,N')platinum (II), R,RG-AMP produced comparable or superior anti-tumor activity to cisplatin, carboplatin, and tetraplatin. Efficacy was also demonstrated for the L1210/DDP (cisplatin-resistant) leukemia. Further, R,R-G-AMP is non-nephrotoxic and produces less leukopenia than cisplatin, carboplatin, and tetraplatin.
AuthorsA H Talebian, D Bensely, P S Schein, D Green
JournalAnti-cancer drug design (Anticancer Drug Des) Vol. 5 Issue 4 Pg. 371-8 (Nov 1990) ISSN: 0266-9536 [Print] ENGLAND
PMID2291775 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Antineoplastic Agents
  • Carbohydrates
  • Organoplatinum Compounds
  • Water
  • Animals
  • Antineoplastic Agents (chemical synthesis, pharmacology, toxicity)
  • Bone Marrow (drug effects)
  • Carbohydrates (pharmacology)
  • Kidney (drug effects)
  • Mice
  • Organoplatinum Compounds (chemical synthesis, pharmacology, toxicity)
  • Solubility
  • Water

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