Abstract |
A series of new water soluble sugar and non- sugar containing platinum(II) complexes was synthesized and evaluated for effects of the sugar moiety on water solubility, anti- tumor activity, and acute leukopenia. When tested in vivo against the murine P388 and L1210 leukemias at LD10/maximally effective doses, the compound cis-[(gluconylamino)malonato-O,O'](1R,2R-cyclohexanediami ne-N,N') platinum (II), R,RG- AMP produced comparable or superior anti- tumor activity to cisplatin, carboplatin, and tetraplatin. Efficacy was also demonstrated for the L1210/DDP ( cisplatin-resistant) leukemia. Further, R,R-G- AMP is non-nephrotoxic and produces less leukopenia than cisplatin, carboplatin, and tetraplatin.
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Authors | A H Talebian, D Bensely, P S Schein, D Green |
Journal | Anti-cancer drug design
(Anticancer Drug Des)
Vol. 5
Issue 4
Pg. 371-8
(Nov 1990)
ISSN: 0266-9536 [Print] United States |
PMID | 2291775
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Antineoplastic Agents
- Carbohydrates
- Organoplatinum Compounds
- Water
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Topics |
- Animals
- Antineoplastic Agents
(chemical synthesis, pharmacology, toxicity)
- Bone Marrow
(drug effects)
- Carbohydrates
(pharmacology)
- Kidney
(drug effects)
- Mice
- Organoplatinum Compounds
(chemical synthesis, pharmacology, toxicity)
- Solubility
- Water
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