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Effect of submucosal injection of dexamethasone on post-operative sequelae of third molar surgery.

AbstractOBJECTIVE:
This study was carried out to evaluate the effects of a single pre-operative sub-mucosal injection of dexamethasone after third molar surgery to see the effects on post-operative discomfort.
METHODS:
This study was a prospective, double-blind, randomized, clinical trial. The subjects were forty patients who underwent surgical removal of the mandibular impacted third molar under local anesthesia and after being randomly assigned to receive either an 8 mg dexamethasone as submucosal injection or a normal saline injection into the lower buccal vestibule adjacent to the third molar. The maximum interincisal distance and facial contours were measured at the baseline and post-surgically on Day 2 and 7. Post-operative pain was evaluated subjectively using a visual analog scale and objectively by counting the number of analgesic tablets used. All subjects were operated upon by the same investigator to minimize the difference from inter-operator variability.
RESULTS:
There was a significant difference in the measurements of the degree of swelling and trismus between the two groups on the 2nd post-operative day. In contrast, there was no statistically significant difference between the groups on the 7th post-operative day. The test group also used fewer analgesics post-operatively.
CONCLUSIONS:
Submucosal injection of dexamethasone after third molar surgery is effective in reducing postoperative swelling and trismus. It also delays the onset of post-operative pain.
AuthorsS P Deo
JournalJNMA; journal of the Nepal Medical Association (JNMA J Nepal Med Assoc) 2011 Apr-Jun Vol. 51 Issue 182 Pg. 72-8 ISSN: 0028-2715 [Print] Nepal
PMID22916516 (Publication Type: Journal Article, Randomized Controlled Trial)
Chemical References
  • Anti-Inflammatory Agents
  • Glucocorticoids
  • Dexamethasone
Topics
  • Adult
  • Anti-Inflammatory Agents (administration & dosage)
  • Dexamethasone (administration & dosage)
  • Edema (prevention & control)
  • Female
  • Glucocorticoids (administration & dosage)
  • Humans
  • Male
  • Molar, Third (surgery)
  • Pain Measurement
  • Pain, Postoperative (prevention & control)
  • Prospective Studies
  • Young Adult

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