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KIOM-79 protects AGE-induced retinal pericyte apoptosis via inhibition of NF-kappaB activation in vitro and in vivo.

Abstract
KIOM-79 is an herbal mixture of parched Puerariae radix, gingered Magnoliae cortex, Glycyrrhizae radix and Euphorbiae radix. In the present study, we determined the efficacy and possible mechanism of KIOM-79 on the advanced glycation end product (AGE)-modified bovine serum albumin (BSA)-induced apoptosis of cultured bovine retinal pericytes and rat retinal pericytes in Zucker diabetic fatty (ZDF) rats. Seven-week-old male ZDF rats were treated with KIOM-79 (50 mg/kg body weight) once a day orally for 13 weeks. KIOM-79 significantly inhibited pericyte apoptosis which were induced by the AGE-BSA treatment. The KIOM-79 treatment markedly suppressed the activation of nuclear factor-kappaB (NF-κB) through the inhibition of inhibitory κB kinase complex. In addition, the oral administration of KIOM-79 inhibited the changes in retinal vasculature (vascular hyperpermeability, acellular capillary). KIOM-79 strongly inhibited pericyte apoptosis, NF-κB activation and the expression of pro-apoptotic Bax and tumor necrosis factor-α. Our results suggest that KIOM-79 may exert inhibitory effects on AGE-induced pericyte apoptosis by blocking NF-κB activation, thereby ameliorating retinal microvascular dysfunction.
AuthorsJunghyun Kim, Chan-Sik Kim, Eunjin Sohn, Yun Mi Lee, Kyuhyung Jo, Jin Sook Kim
JournalPloS one (PLoS One) Vol. 7 Issue 8 Pg. e43591 ( 2012) ISSN: 1932-6203 [Electronic] United States
PMID22916281 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Glycation End Products, Advanced
  • KIOM 79
  • NF-kappa B
  • Plant Extracts
  • advanced glycation end products-bovine serum albumin
  • Serum Albumin, Bovine
Topics
  • Animals
  • Apoptosis (drug effects)
  • Blotting, Western
  • Cells, Cultured
  • Diabetic Retinopathy (drug therapy, metabolism)
  • Enzyme-Linked Immunosorbent Assay
  • Glycation End Products, Advanced (pharmacology)
  • Male
  • NF-kappa B (metabolism)
  • Pericytes (cytology, drug effects, metabolism)
  • Plant Extracts (pharmacology, therapeutic use)
  • Rats
  • Serum Albumin, Bovine (pharmacology)

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