High hepatitis B surface antigen levels predict insignificant fibrosis in hepatitis B e antigen positive chronic hepatitis B.

Abstract

INTRODUCTION:

There is no data on the relationship between hepatitis B surface antigen (HBsAg) levels and liver fibrosis in hepatitis B e antigen (HBeAg)-positive patients with chronic hepatitis B (CHB).

METHODS:

Serum HBsAg and HBV DNA levels in HBeAg-positive CHB patients with liver biopsies were analyzed. The upper limit of normal (ULN) of alanine aminotransferase (ALT) was 30 and 19 U/L for men and women respectively. Histologic assessment was based on Ishak fibrosis staging for fibrosis and Knodell histologic activity index (HAI) for necroinflammation.

RESULTS:

140 patients (65% male, median age 32.7 years) were recruited. 56 (40%) had ALT ≤2×ULN. 72 (51.4%) and 42 (30%) had fibrosis score ≤ 1 and necroinflammation grading ≤ 4 respectively. Patients with fibrosis score ≤ 1, when compared to patients with fibrosis score >1, had significantly higher median HBsAg levels (50,320 and 7,820 IU/mL respectively, p<0.001). Among patients with ALT ≤2×ULN, serum HBsAg levels achieved an area under receiver operating characteristic curve of 0.869 in predicting fibrosis score ≤ 1. HBsAg levels did not accurately predict necroinflammation score. HBsAg ≥ 25,000 IU/mL was independently associated with fibrosis score ≤ 1 (p=0.025, odds ratio 9.042).Using this cut-off HBsAg level in patients with ALT ≤2×ULN, positive and negative predictive values for predicting fibrosis score ≤ 1 were 92.7% and 60.0% respectively. HBV DNA levels had no association with liver histology.

CONCLUSION:

Among HBeAg-positive patients with ALT ≤2×ULN, high serum HBsAg levels can accurately predict fibrosis score ≤ 1, and could potentially influence decisions concerning treatment commencement and reduce the need for liver biopsy.

• Authors: Wai-Kay Seto, Danny Ka-Ho Wong, James Fung, Philip P C Ip, John Chi-Hang Yuen, Ivan Fan-Ngai Hung, Ching-Lung Lai, Man-Fung Yuen
• Journal: PloS one (PLoS One) Vol. 7 Issue 8 Pg. e43087 ( 2012) ISSN: 1932-6203 [Electronic] United States
• PMID: 22916211 (Publication Type: Journal Article)

Chemical References

• Hepatitis B Surface Antigens
• Hepatitis B e Antigens

Topics

• Adolescent
• Adult
• Female
• Hepatitis B Surface Antigens (blood, metabolism)
• Hepatitis B e Antigens (blood, metabolism)
• Hepatitis B, Chronic (blood, metabolism, pathology)
• Humans
• Liver Cirrhosis (metabolism)
• Male
• Middle Aged
• Multivariate Analysis
• Young Adult