Abstract |
Intravesical instillation therapy with (2"R)-4'-O-tetrahydropyranyl adriamycin [ pirarubicin ( THP)], a new anthracycline agent, was performed to examine its direct effect on superficial bladder cancer in a six-center cooperative Phase II study. There were 50 evaluable cases, for which a response rate of 50% was obtained. The main side effects that occurred were bladder irritation symptoms such as pollakisuria (50%) and pain on urination (38%). Intravesical pirarubicin instillation therapy was administered to eight cases that had not responded to doxorubicin therapy or that had experienced recurrence after such therapy. For six evaluable cases, the response rate was 50%, and the incidence of side effects was 88%.
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Authors | Y Matsumura |
Journal | American journal of clinical oncology
(Am J Clin Oncol)
Vol. 13 Suppl 1
Pg. S5-10
( 1990)
ISSN: 0277-3732 [Print] United States |
PMID | 2291459
(Publication Type: Clinical Trial, Journal Article, Multicenter Study)
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Chemical References |
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Topics |
- Administration, Intravesical
- Adult
- Aged
- Aged, 80 and over
- Doxorubicin
(administration & dosage, analogs & derivatives, therapeutic use)
- Drug Evaluation
- Female
- Humans
- Male
- Middle Aged
- Neoplasm Staging
- Urinary Bladder Neoplasms
(drug therapy, pathology)
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