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[Efficacy of albendazole for treatment of mice infected with Sparganum mansoni].

Abstract
In order to observe the efficacy of albendazole for the treatment of mice infected with Sparganum mansoni, a total of 72 mice were divided into 8 groups (9 mice each), each mouse was orally infected with 5 plerocercoid. At one week after infection, groups A-C were treated with a 7-day course of albendazole (1700, 2500, and 3300 mg/kg, twice daily), and sacrificed at 1 week post-treatment; groups E-G were treated with the second course of albendazole with the same dosage at 1 week interval after the first course, and sacrificed at 1 week after the second course; the groups D and H were used as control for A-C and E-G, respectively. After the infected mice were sacrificed, the mean number of worms recovered was observed and worm reduction rate was determined. When treating with one course of albendazole at 1 week post infection, the worm reduction rate in groups A-C was 20.0%, 20.0% and 24.9%, respectively (chi2 = 0.351, P > 0.05). After treatment with two courses of albendazole, the worm reduction rate in groups E-G was 22.3%, 36.4% and 31.9% (chi2 = 1.812, P > 0.05). The difference of the worm reduction rate in the infected mice treated with 1 and 2 courses of albendazole showed no statistical significance (P > 0.05). The results indicated albendazole has no obvious efficacy for treating sparganosis in mice.
AuthorsJing Cui, Ming-ming Wang, Yu-wei Zhao, Guan-hua Gan, Bo-wen Hu, Peng Jiang, Xin Qi, Li-na Liu, Zhong-quan Wang
JournalZhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases (Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi) Vol. 30 Issue 1 Pg. 71-2 (Feb 29 2012) ISSN: 1000-7423 [Print] China
PMID22913197 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Albendazole
Topics
  • Albendazole (therapeutic use)
  • Animals
  • Disease Models, Animal
  • Male
  • Mice
  • Mice, Inbred Strains
  • Sparganosis (drug therapy)
  • Sparganum (drug effects)
  • Treatment Outcome

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