Abstract | BACKGROUND: METHODS: RESULTS: Patients with cirrhosis had a more extensive platelet area in the liver compared to controls (5601 ± 5611 vs. 564 ± 361 μm(2), p = 0.02), although the blood platelet count significantly decreased along with the progression of liver fibrosis. In cirrhotic liver, most platelets were present in the sinusoidal space of the periportal area with inflammation, where HSCs expressing PDGF receptor-β were frequently observed. In addition, the platelet and Kupffer cell areas were significantly smaller in cancerous tissue than those in noncancerous tissues (platelet area: 492 ± 823 vs. 3643 ± 4055 μm(2), p = 0.001; Kupffer cell area: 450 ± 841 vs. 3012 ± 3051 μm(2), p = 0.001). CONCLUSIONS: The accumulation of platelets in the liver with chronic hepatitis may be involved in thrombocytopenia and liver fibrosis through the activation of HSCs. In addition, our findings also indicate that both platelets and Kupffer cells decrease in HCC tissues.
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Authors | Reiichiro Kondo, Hirohisa Yano, Osamu Nakashima, Ken Tanikawa, Yoriko Nomura, Masayoshi Kage |
Journal | Journal of gastroenterology
(J Gastroenterol)
Vol. 48
Issue 4
Pg. 526-34
(Apr 2013)
ISSN: 1435-5922 [Electronic] Japan |
PMID | 22911171
(Publication Type: Journal Article)
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Topics |
- Aged
- Blood Platelets
(pathology, ultrastructure)
- Carcinoma, Hepatocellular
(surgery, virology)
- Female
- Hepatectomy
- Hepatic Stellate Cells
(pathology, ultrastructure)
- Hepatitis C, Chronic
(complications, pathology)
- Humans
- Kupffer Cells
(pathology)
- Liver
(ultrastructure)
- Liver Cirrhosis
(pathology, virology)
- Liver Neoplasms
(surgery, virology)
- Male
- Microscopy, Electron
- Middle Aged
- Platelet Count
- Severity of Illness Index
- Thrombocytopenia
(pathology, virology)
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