[Effect of Ingavirin on the ultrastructure of the morphogenesis of adenovirus infection in vivo].

Abstract

The goal of this study was to evaluate the effect of Ingavirin on the morphological features of the foci of adenovirus hepatitis in Syrian hamsters by electron microscopy. The use of the drug was shown to cause a substantial reduction in the rate of destructive processes and inflammatory reactions in the liver, by normalizing its structure at the levels of both tissue and individual hepatocytes. After administration of Ingavirin, the morphogenesis of adenovirus infection in the infected hepatocytes did not differ from that in the controls; however, the infected cells were fewer. The proportion of morphologically inadequate virions in the presence of Ingavirin increased from 35 to 46%. The findings suggest that Ingavirin is an effective drug that has antiviral, anti-inflammatory, and cytoprotective activities in the focus of adenovirus tissue involvement.

• Authors: V V Zarubaev, A V Slita, A K Sirotkin, S V Beliavskaia, V E Nebol'sin, D V Reĭkhart, O I Kiselev
• Journal: Voprosy virusologii (Vopr Virusol) 2012 May-Jun Vol. 57 Issue 3 Pg. 17-23 ISSN: 0507-4088 [Print] Russia (Federation)
• PMID: 22905422 (Publication Type: Journal Article)

Chemical References

• Amides
• Caproates
• Dicarboxylic Acids
• Imidazoles
• pentanedioic acid imidazolyl ethanamide

Topics

• Adenoviridae Infections (drug therapy)
• Adenoviruses, Human (drug effects, genetics)
• Amides (administration & dosage)
• Animals
• Caproates
• Cricetinae
• Dicarboxylic Acids (administration & dosage)
• Hepatitis, Animal (drug therapy, virology)
• Hepatocytes (drug effects, ultrastructure)
• Humans
• Imidazoles (administration & dosage)
• Liver (drug effects, ultrastructure)
• Mesocricetus
• Microscopy, Electron