N-acetyltransferase polymorphism and risk of colorectal adenoma and cancer: a pooled analysis of variations from 59 studies.

Abstract

BACKGROUND:

There have been an increasing number of studies with evidence suggesting that the N-acetyltransferase 1 (NAT1) and N-acetyltransferase 2 (NAT2) genotypes may be implicated in the development of colorectal cancer (CRC) and colorectal adenoma (CRA). So far the published data on this association has remained controversial, however. We performed a meta-analysis of case-cohort and case-control studies using a subset of the published data, with an aim to derive a better understanding of the underlying relationship.

METHODS/PRINCIPAL FINDINGS:

A literature search was performed using Medline database for relevant studies published through October 31, 2011. A total of 39 publications were selected for this meta-analysis, including 11,724 cases and 16,215 controls for CRC, and 3,701 cases and 5,149 controls for CRA. In our pooled analysis of all these studies, the results of our meta-analysis suggested that the NAT1 genotype was not significantly associated with an elevated CRC risk (OR 0.99, 95% CI 0.91-1.07). We also found that individuals with the rapid NAT2 genotype did have an elevated risk of CRC (OR 1.07, 95% CI 1.01-1.13). There was no evidence for an association between the NAT1 and 2 rapid genotype and an elevated CRA risk (NAT1: OR 1.14, 95% CI 0.99-1.29; NAT2: OR 0.94, 95% CI 0.86-1.03).

CONCLUSION:

This meta-analysis suggests that individuals with NAT2 genotype had an elevated risk of CRC. There was no evidence for the association between NAT1 and 2 rapid genotype and CRA risk.

• Authors: Jinxin Liu, Dapeng Ding, Xiaoxue Wang, Yizhi Chen, Rong Li, Ying Zhang, Rongcheng Luo
• Journal: PloS one (PLoS One) Vol. 7 Issue 8 Pg. e42797 ( 2012) ISSN: 1932-6203 [Electronic] United States
• PMID: 22905173 (Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't)

Chemical References

• Isoenzymes
• Acetyltransferases
• Arylamine N-Acetyltransferase
• N-acetyltransferase 1
• NAT2 protein, human

Topics

• Acetyltransferases (genetics)
• Adenoma (genetics)
• Arylamine N-Acetyltransferase (genetics, physiology)
• Case-Control Studies
• Cohort Studies
• Colorectal Neoplasms (genetics)
• Gene Expression Regulation, Neoplastic
• Genetic Predisposition to Disease
• Genetic Variation
• Genotype
• Humans
• Isoenzymes (genetics, physiology)
• Polymorphism, Genetic
• Risk