Abstract |
The purpose of this study was to investigate possible molecular targets involved in the neuroprotective effect of p,p'-methoxyl-diphenyl diselenide [( MeOPhSe)2], using a streptozotocin (STZ)-induced sporadic dementia of Alzheimer's type rat model. Male Wistar rats were injected with STZ (1.0 mg/8 μl; 4 μl/ventricle). After 21 days of STZ injection, regular diet-fed rats were supplemented with 10 ppm of ( MeOPhSe)2 during 30 days. At the end of this period, rats performed object recognition and step-down passive avoidance tasks. Apoptosis was assessed by TUNEL staining and active caspase-3. Glial fibrillary acidic protein, ionized calcium binding adaptor molecule 1, and microtubule associated protein 2 were determined by immunofluorescence in rat hippocampus. The results demonstrate that the ( MeOPhSe)2 dietary supplementation reversed STZ-induced memory impairment by enhancing memory in sham rats. ( MeOPhSe)2 was also effective in reducing STZ-induced apoptosis and preserving dendrites and synapses. Moreover, ( MeOPhSe)2 inhibited activation of microglia and astrogliosis induced by STZ in the rat hippocampus. We conclude that the ( MeOPhSe)2 neuroprotective action is related to inhibition of apoptosis and suppression of inflammation.
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Authors | Simone Pinton, Tuane Bazanella Sampaio, Rita M Ramalho, Cecília M P Rodrigues, Cristina Wayne Nogueira |
Journal | Journal of Alzheimer's disease : JAD
(J Alzheimers Dis)
Vol. 33
Issue 1
Pg. 133-44
( 2013)
ISSN: 1875-8908 [Electronic] Netherlands |
PMID | 22903129
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Benzene Derivatives
- Neuroprotective Agents
- Organoselenium Compounds
- p-methoxy-diphenyl diselenide
- Streptozocin
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Topics |
- Animals
- Benzene Derivatives
(pharmacology, therapeutic use)
- Exploratory Behavior
(drug effects, physiology)
- Male
- Memory
(drug effects, physiology)
- Neurodegenerative Diseases
(chemically induced, metabolism, pathology, prevention & control)
- Neuroglia
(drug effects, metabolism, pathology)
- Neuroprotective Agents
(pharmacology, therapeutic use)
- Organoselenium Compounds
(pharmacology, therapeutic use)
- Rats
- Rats, Wistar
- Streptozocin
(toxicity)
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