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Passive immunization with tenascin-R (TN-R) polyclonal antibody promotes axonal regeneration and functional recovery after spinal cord injury in rats.

Abstract
Tenascin-R (TN-R) is a neural specific protein and an important molecule involved in inhibition of axonal regeneration after spinal cord injury (SCI). Here we report on rabbit-derived TN-R polyclonal antibody, which acts as a TN-R antagonist with high titer and high specificity, promoted neurite outgrowth and sprouting of rat cortical neurons cultured on the inhibitory TN-R substrate in vitro. When locally administered into the lesion sites of rats received spinal cord dorsal hemisection, these TN-R antibodies could significantly decrease RhoA activation and improve functional recovery from corticospinal tract (CST) transection. Thus, passive immunotherapy with specific TN-R antagonist may represent a promising repair strategy following acute SCI.
AuthorsJian You, Sun-Quan Hong, Mao-Ying Zhang, Hai-Lin Zhao, Tian-Zhu Liu, Hong-Long Zhou, Ying-Qian Cai, Zhi-Min Xu, Yang Guo, Xiao-Dan Jiang, Ru-Xiang Xu
JournalNeuroscience letters (Neurosci Lett) Vol. 525 Issue 2 Pg. 129-34 (Sep 13 2012) ISSN: 1872-7972 [Electronic] Ireland
PMID22902990 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2012 Elsevier Ireland Ltd. All rights reserved.
Chemical References
  • Antibodies
  • Tenascin
  • tenascin R
  • rhoA GTP-Binding Protein
Topics
  • Animals
  • Animals, Newborn
  • Antibodies (pharmacology, therapeutic use)
  • Axons (drug effects, physiology)
  • Cells, Cultured
  • Female
  • Hindlimb (physiopathology)
  • Immunization, Passive
  • Motor Activity
  • Nerve Regeneration
  • Neurites (drug effects, physiology)
  • Rabbits
  • Rats
  • Rats, Sprague-Dawley
  • Spinal Cord Injuries (immunology, physiopathology, therapy)
  • Tenascin (antagonists & inhibitors, immunology)
  • rhoA GTP-Binding Protein (metabolism)

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