The risks, degree of malignancy and clinical progression of prostate cancer associated with the MDM2 T309G polymorphism: a meta-analysis.

Abstract

To determine the risk, malignant degree and clinical progression of prostate cancer (PCa) associated with mouse double-minute 2 protein (MDM2) T309G variants, a meta-analysis was performed on all eligible published studies. Odds ratios (ORs) with 95% confidence intervals (CIs) were estimated to assess these associations in seven studies that included 5151 cases and 1003 controls. In the overall analysis, the 309G allele was significantly associated with a decreased PCa risk (OR=0.85, 95% CI: 0.74-0.97); this was also the case for the homozygous comparison (OR=0.72, 95% CI: 0.55-0.95) and the dominant genetic model (OR=0.79, 95% CI: 0.65-0.96). The 309G allele was also found to be significantly associated with lower degrees of PCa malignancy (OR=0.85, 95% CI: 0.75-0.96) in the overall analysis, as well as in the heterozygous comparison (OR=0.79, 95% CI: 0.65-0.96), homozygous comparison (OR=0.76, 95% CI: 0.58-0.98) and dominant genetic model (OR=0.81, 95% CI: 0.68-0.96). Furthermore, grouping analysis showed that the 309G allele in Caucasians was significantly correlated with a decreased PCa risk (OR=0.77, 95% CI: 0.61-0.96); this was also the case in the homozygous comparison (OR=0.51, 95% CI: 0.31-0.86). The grouping analysis also showed that the 309G variant in Caucasians was significantly associated with a lower degree of PCa malignancy in all of the genetic models. In addition, we found that the 309G variant in Caucasians was significantly associated with a slower PCa clinical progression in all of the genetic models. In summary, our meta-analysis showed that the MDM2 309G variant was significantly associated with a decreased PCa risk, lower malignant degree and slower clinical progression in Caucasians, but there was no obvious association in the Asian population.

• Authors: Jie Yang, Wen Gao, Ning-Hong Song, Wei Wang, Jie-Xiu Zhang, Pei Lu, Li-Xin Hua, Min Gu
• Journal: Asian journal of andrology (Asian J Androl) Vol. 14 Issue 5 Pg. 726-31 (Sep 2012) ISSN: 1745-7262 [Electronic] China
• PMID: 22902907 (Publication Type: Journal Article, Meta-Analysis)

Chemical References

• MDM2 protein, human
• Proto-Oncogene Proteins c-mdm2

Topics

• Alleles
• Disease Progression
• Genetic Predisposition to Disease
• Genotype
• Humans
• Male
• Polymorphism, Genetic
• Prostatic Neoplasms (genetics, pathology)
• Proto-Oncogene Proteins c-mdm2 (genetics)
• Risk Factors