Abstract | BACKGROUND: METHODS: RESULTS:
Infarct volumes 24 hours after permanent middle cerebral artery occlusion were significantly smaller in neuroglobin-null mice than in wild-types (p < 0.01). Neuroglobin immunostaining of the penumbra area revealed no visible up-regulation of neuroglobin protein in ischemic wild-type mice when compared to uninjured wild-type mice. In uninjured wild-type mice, neuroglobin protein was seen throughout cortical layer II and sparsely in layer V. In contrast, no neuroglobin-immunoreactive neurons were observed in the aforementioned layers of the ischemia injured cortical area, or in the surrounding penumbra of ischemic wild-type mice. This suggests no selective sparing of neuroglobin expressing neurons in ischemia. CONCLUSIONS:
Neuroglobin-deficiency resulted in reduced tissue infarction, suggesting that, at least at endogenous expression levels, neuroglobin in itself is non-protective against ischemic injury.
|
Authors | Zindy Raida, Christian Ansgar Hundahl, Jesper Kelsen, Jens Randel Nyengaard, Anders Hay-Schmidt |
Journal | Experimental & translational stroke medicine
(Exp Transl Stroke Med)
Vol. 4
Issue 1
Pg. 15
(08 20 2012)
ISSN: 2040-7378 [Electronic] England |
PMID | 22901501
(Publication Type: Journal Article)
|