2R of thymidylate synthase 5'-untranslated enhanced region contributes to gastric cancer risk: a meta-analysis.

Abstract

BACKGROUND:

Studies investigating the association between 2R/3R polymorphisms in the thymidylate synthase 5'-untranslated enhanced region (TYMS 5'-UTR) and gastric cancer risk have generated conflicting results. Thus, a meta-analysis was performed to summarize the data on any association.

METHODS:

Pubmed, Embase, and CNKI databases were searched for all available studies. The strength of association between TYMS 5'-UTR 2R/3R polymorphism and gastric cancer risk was estimated by odds ratios (ORs) with 95% confidence intervals (CIs).

RESULTS:

Six individual case-control studies with a total of 1,472 cases and 1,895 controls were included into this meta-analysis. Analyses of total six relevant studies showed that there was no obvious association between the TYMS 5'-UTR 2R/3R polymorphism and gastric cancer risk. Subgroup analyses based on ethnicity showed 2R of TYMS 5'-UTR 2R/3R contributes to gastric cancer risk in the Asian population (ORHomozygote model=1.71, 95%CI 1.19-2.46, P=0.004; ORRecessive genetic model=1.70, 95%CI 1.18-2.43, P=0.004). However, the association in Caucasian populations was uncertain due to the limited studies.

CONCLUSIONS:

Our meta-analysis suggests that 2R of TYMS 5'-UTR 2R/3R contributes to gastric cancer risk in the Asian population, while this association in Caucasians populations needs further study.

• Authors: Zhen Yang, Hong-Xiang Liu, Xie-Fu Zhang
• Journal: Asian Pacific journal of cancer prevention : APJCP (Asian Pac J Cancer Prev) Vol. 13 Issue 5 Pg. 1923-7 ( 2012) ISSN: 2476-762X [Electronic] Thailand
• PMID: 22901148 (Publication Type: Journal Article, Meta-Analysis)

Chemical References

• 5' Untranslated Regions
• Thymidylate Synthase

Topics

• 5' Untranslated Regions (genetics)
• Case-Control Studies
• Genetic Predisposition to Disease
• Humans
• Polymorphism, Genetic (genetics)
• Prognosis
• Stomach Neoplasms (enzymology, etiology)
• Thymidylate Synthase (genetics)