Abstract | BACKGROUND: Studies investigating the association between 2R/3R polymorphisms in the thymidylate synthase 5'-untranslated enhanced region (TYMS 5'-UTR) and gastric cancer risk have generated conflicting results. Thus, a meta-analysis was performed to summarize the data on any association. METHODS: Pubmed, Embase, and CNKI databases were searched for all available studies. The strength of association between TYMS 5'-UTR 2R/3R polymorphism and gastric cancer risk was estimated by odds ratios ( ORs) with 95% confidence intervals (CIs). RESULTS: Six individual case-control studies with a total of 1,472 cases and 1,895 controls were included into this meta-analysis. Analyses of total six relevant studies showed that there was no obvious association between the TYMS 5'-UTR 2R/3R polymorphism and gastric cancer risk. Subgroup analyses based on ethnicity showed 2R of TYMS 5'-UTR 2R/3R contributes to gastric cancer risk in the Asian population (ORHomozygote model=1.71, 95%CI 1.19-2.46, P=0.004; ORRecessive genetic model=1.70, 95%CI 1.18-2.43, P=0.004). However, the association in Caucasian populations was uncertain due to the limited studies. CONCLUSIONS: Our meta-analysis suggests that 2R of TYMS 5'-UTR 2R/3R contributes to gastric cancer risk in the Asian population, while this association in Caucasians populations needs further study.
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Authors | Zhen Yang, Hong-Xiang Liu, Xie-Fu Zhang |
Journal | Asian Pacific journal of cancer prevention : APJCP
(Asian Pac J Cancer Prev)
Vol. 13
Issue 5
Pg. 1923-7
( 2012)
ISSN: 2476-762X [Electronic] Thailand |
PMID | 22901148
(Publication Type: Journal Article, Meta-Analysis)
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Chemical References |
- 5' Untranslated Regions
- Thymidylate Synthase
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Topics |
- 5' Untranslated Regions
(genetics)
- Case-Control Studies
- Genetic Predisposition to Disease
- Humans
- Polymorphism, Genetic
(genetics)
- Prognosis
- Stomach Neoplasms
(enzymology, etiology)
- Thymidylate Synthase
(genetics)
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