Abstract | BACKGROUND AND OBJECTIVES: The production of reactive oxygen species (ROS) is one of the mechanisms of laser irradiation in the skin, and there are beneficial and detrimental aspects to this reaction. Detrimental side effects after laser treatments, such as redness and pigmentation, can be reduced by using anti-oxidants. MATERIALS AND METHODS: Electron spin resonance (ESR) analysis using a free radical trapping agent revealed that different free radicals, including hydroxyl ((·) OH) and superoxide anion (O 2-) radicals, were generated in the skin of hairless mice by irradiation with intense pulsed light (IPL), plasma, and radio frequency lasers. RESULTS: Generation of O 2- and (·) OH radicals was significantly inhibited in a dose-dependent fashion by fullerene and fullerene did not have any pro-oxidant effects as no radical adduct signal was detected. Although ROS can increase expression of COX-2 mRNA, an inflammatory marker, laser-induced COX-2 expression was significantly suppressed by the antioxidant activity of fullerene. In addition, imaging analysis of human skin has shown that erythema-associated redness caused by laser-induced inflammation is inhibited by fullerene gel. CONCLUSION:
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Authors | Takahiro Fujimoto, Shinobu Ito, Masayuki Ito, Hideko Kanazawa, Shigeru Yamaguchi |
Journal | Lasers in surgery and medicine
(Lasers Surg Med)
Vol. 44
Issue 8
Pg. 685-94
(Oct 2012)
ISSN: 1096-9101 [Electronic] United States |
PMID | 22899448
(Publication Type: Journal Article)
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Copyright | Copyright © 2012 Wiley Periodicals, Inc. |
Chemical References |
- Antioxidants
- Fullerenes
- RNA, Messenger
- Reactive Oxygen Species
- Cyclooxygenase 2
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Topics |
- Animals
- Antioxidants
(administration & dosage)
- Cyclooxygenase 2
(genetics, metabolism)
- Dose-Response Relationship, Drug
- Electron Spin Resonance Spectroscopy
- Fullerenes
(administration & dosage)
- Guinea Pigs
- Humans
- Hyperpigmentation
(prevention & control)
- Lasers
- Mice
- Models, Animal
- RNA, Messenger
(metabolism)
- Reactive Oxygen Species
(metabolism)
- Skin
(metabolism)
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