Imaging findings in 75 pediatric patients with pancreaticobiliary maljunction: a retrospective case study.

Abstract

BACKGROUND:

Pancreaticobiliary maljunction (PBM) is often associated with congenital choledochal cyst, protein plugs and pancreatitis. Early diagnosis and timely treatment largely depend on imaging. We assessed a series of PBM in children, comparing imaging procedure with histological and pathological findings with regard to diagnosis.

METHODS:

A retrospective analysis was conducted in 75 pediatric patients with PBM. PBM was defined as common channel at >5 mm. Two radiologists assess the shape of the bile duct and gallbladder, pancreatitis, surgical pathology, symptom profiles, operative notes and pathological records were compared with the imaging findings.

RESULTS:

Dilatation of the bile duct was detected in 45 subjects out of the 46 subjects who underwent computed tomography (CT) and nine was diagnosis as PBM. Forty out of 41 subjects were revealed bile duct dilatation in ultrasonography (US). Bile duct dilatation was seen in 59 out of 60 subjects receiving magnetic resonance cholangiopancreatography (MRCP) and 39 were diagnosed as PBM. Seventy-four out of 75 subjects successfully underwent intraoperative cholangiography (IOC); a diagnosis of PBM was established in 60 cases based on IOC alone. The diagnosis rate of pediatric PBM varied significantly among the four groups (P < 0.0001). Pair-wise comparison showed a significant difference between the groups of MRCP and CT (P < 0.0001), MRCP and US (P < 0.0001), IOC and CT (P < 0.0001), IOC and US (P < 0.0001), CT and US (P = 0.0027), and there is no significant difference between the groups of IOC and MRCP (P = 0.0502).

CONCLUSION:

US, IOC, CT and MRCP are valuable in showing dilatation of the bile duct and complications in pediatric PBM. MRCP is non-invasive, gives clear views of the pancreaticobiliary junction and should be the first choice for the diagnosis of PBM in children.

• Authors: Wan-liang Guo, Shun-gen Huang, Jian Wang, Mao Sheng, Lin Fang
• Journal: Pediatric surgery international (Pediatr Surg Int) Vol. 28 Issue 10 Pg. 983-8 (Oct 2012) ISSN: 1437-9813 [Electronic] Germany
• PMID: 22892909 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Topics

• Adolescent
• Bile Ducts (abnormalities, surgery)
• Child
• Child, Preschool
• Cholangiopancreatography, Endoscopic Retrograde (methods)
• Cholangiopancreatography, Magnetic Resonance (methods)
• Diagnosis, Differential
• Diagnostic Imaging (methods)
• Digestive System Abnormalities (diagnosis, surgery)
• Digestive System Surgical Procedures (methods)
• Female
• Follow-Up Studies
• Humans
• Infant
• Male
• Pancreatic Ducts (abnormalities, surgery)
• Retrospective Studies
• Tomography, X-Ray Computed (methods)